Long-term topical bevacizumab for prevention of corneal graft rejections
| العنوان: | Long-term topical bevacizumab for prevention of corneal graft rejections |
|---|---|
| المؤلفون: | Elizabeth P. Shen, Hua-Hsuan Kuo |
| المصدر: | European Journal of Ophthalmology. 31:NP48-NP52 |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Graft Rejection, 0301 basic medicine, medicine.medical_specialty, genetic structures, Bevacizumab, Corneal graft, 03 medical and health sciences, 0302 clinical medicine, Ophthalmology, medicine, Humans, Corneal Neovascularization, Retrospective Studies, Graft rejection, business.industry, Graft Survival, General Medicine, medicine.disease, eye diseases, 030104 developmental biology, Corneal neovascularization, 030221 ophthalmology & optometry, sense organs, business, Keratoplasty, Penetrating, medicine.drug |
| الوصف: | Purpose: To evaluate the safety and efficacy of 1% topical bevacizumab (10 mg/mL) on newly formed corneal neovascularization (NV) after penetrating keratoplasty (PK). Methods: This is a retrospective case series reporting three eyes (three patients) of with newly formed corneal NV after corneal transplantation. All eyes had pre-existing corneal NVs and were high risk corneal graft rejection cases. One percent topical bevacizumab was started immediately after corneal NV formation post-PK. Topical bevacizumab was kept at twice weekly throughout the follow-up period. Results: Regression of corneal NV without donor graft invasion was noted in all three patients (100%). Duration of topical bevacizumab use was 13 to 36 months. All three corneal grafts (100%) remained clear and no signs of graft rejection were noted for the period of observation. There were no associated systemic or ocular adverse effects. Conclusion: Long-term use of topical 1% bevacizumab may be a safe and efficient treatment for corneal NVs and prevention of graft rejections after corneal transplantation. |
| تدمد: | 1724-6016 1120-6721 |
| DOI: | 10.1177/1120672120939504 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c1028a47b0ac391bf3bd7a7ad61da9 https://doi.org/10.1177/1120672120939504 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f1c1028a47b0ac391bf3bd7a7ad61da9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17246016 11206721 |
|---|---|
| DOI: | 10.1177/1120672120939504 |