Hemozoin-generated vapor nanobubbles for transdermal reagent- and needle-free detection of malaria
| العنوان: | Hemozoin-generated vapor nanobubbles for transdermal reagent- and needle-free detection of malaria |
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| المؤلفون: | Dmitri O. Lapotko, Ekaterina Y. Lukianova-Hleb, David J. Sullivan, K. M. Campbell, Russell E. Ware, Janet Braam, John S. Olson, Pamela E. Constantinou |
| المصدر: | Proceedings of the National Academy of Sciences. 111:900-905 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Needle free, Multidisciplinary, Diagnostic methods, Materials science, biology, Hemozoin, Nanotechnology, Plasmodium falciparum, medicine.disease, biology.organism_classification, Reagent, Physical Sciences, parasitic diseases, medicine, Malaria, Blood drawing, Transdermal |
| الوصف: | Successful diagnosis, screening, and elimination of malaria critically depend on rapid and sensitive detection of this dangerous infection, preferably transdermally and without sophisticated reagents or blood drawing. Such diagnostic methods are not currently available. Here we show that the high optical absorbance and nanosize of endogenous heme nanoparticles called “hemozoin,” a unique component of all blood-stage malaria parasites, generates a transient vapor nanobubble around hemozoin in response to a short and safe near-infrared picosecond laser pulse. The acoustic signals of these malaria-specific nanobubbles provided transdermal noninvasive and rapid detection of a malaria infection as low as 0.00034% in animals without using any reagents or drawing blood. These on-demand transient events have no analogs among current malaria markers and probes, can detect and screen malaria in seconds, and can be realized as a compact, easy-to-use, inexpensive, and safe field technology. |
| تدمد: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1316253111 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b1292475b78de9b72ebae2e1c0ad9d https://doi.org/10.1073/pnas.1316253111 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f1b1292475b78de9b72ebae2e1c0ad9d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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| DOI: | 10.1073/pnas.1316253111 |