Toll‐like receptor‐1, ‐2, and ‐6 genotypes in relation to salivary human beta‐defensin‐1, ‐2, ‐3 and human neutrophilic peptide‐1
| العنوان: | Toll‐like receptor‐1, ‐2, and ‐6 genotypes in relation to salivary human beta‐defensin‐1, ‐2, ‐3 and human neutrophilic peptide‐1 |
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| المؤلفون: | Mervi Gürsoy, Eija Könönen, Qiushui He, Anna Liukkonen, Sisko Huumonen, Ulvi Kahraman Gürsoy |
| المصدر: | Journal of Clinical Periodontology. 49:1185-1191 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, alpha-Defensins, Toll-Like Receptor 6, beta-Defensins, Genotype, Humans, Periodontics, Polymorphism, Single Nucleotide, Toll-Like Receptor 1, Toll-Like Receptor 2 |
| الوصف: | To examine whether functional gene polymorphisms of toll-like receptor (TLR)1, TLR2, and TLR6 are related to the salivary concentrations of human beta-defensins (hBDs)-1, -2, -3, and human neutrophilic peptide (HNP)-1.Polymorphisms of TLR1 (rs5743618), TLR2 (rs5743708), and TLR6 (rs5743810) were genotyped by PCR-based pyrosequencing from the salivary samples of 230 adults. Salivary hBD-1, -2, -3, and HNP-1 concentrations were measured using enzyme-linked immunosorbent assay. General and periodontal health examinations, including panoramic radiography, were available for all participants.The genotype frequencies for wild types and variant types were as follows: 66.5% and 33.5% for TLR1, 95.5% and 4.5% for TLR2, and 25.1% and 74.9% for TLR6, respectively. The TLR2 heterozygote variant group exhibited higher salivary hBD-2 concentrations than the TLR2 wild-type group (p = .038). On the contrary, elevated hBD-2 concentrations were detected in the TLR6 wild-type group compared with the TLR6 heterozygote and homozygote variant group (p = .028). The associations between TLR6 genotypes and salivary hBD-2 concentrations remained significant after adjusting them for periodontal status, age, and smoking.hBD-2 concentrations in saliva are related to TLR2 and TLR6 polymorphisms, but only the TLR6 genotype seems to exhibit an independent association with the salivary hBD-2 concentrations. |
| تدمد: | 1600-051X 0303-6979 |
| DOI: | 10.1111/jcpe.13697 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1797b4ffb5620b7bc4e8adc5deb2628 https://doi.org/10.1111/jcpe.13697 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f1797b4ffb5620b7bc4e8adc5deb2628 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1600051X 03036979 |
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| DOI: | 10.1111/jcpe.13697 |