التفاصيل البيبلوغرافية
| العنوان: |
Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40 |
| المؤلفون: |
Alexander G. Dossetter, Helen Pointon, Mark L. Fenwick, Gary Wilkinson, Sam D. Groombridge, David G.A. Morgan, Graeme R. Robb, Susan J. G. Loxham, David Baker, Stuart Norman Lile Bennett, Michael J. Waring, Jenny Morrell, Rob Garcia, Philip A. MacFaul, Jennie Georgsson, David M. Smith, Katie G. Maskill, Stephen Stokes |
| بيانات النشر: |
Royal Society of Chemistry, 2015. |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Pharmacology, endocrine system, Chemistry, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Biochemistry, Combinatorial chemistry, In vivo, Free fatty acid receptor 1, Drug Discovery, Lipophilicity, Molecular Medicine, Potency, QD, Antagonism |
| الوصف: |
A series of 2-(pyridinyl)pyrimidines were identified as potent GPR40 antagonists. Despite significant challenges related to improving the combination of potency and lipophilicity within the series, the compounds were optimised to identify a suitable in vivo probe compound, which was confirmed to exhibit pharmacology consistent with GPR40 antagonism. |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2040-2511 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f148b3f7ff76822b87760b13cc1915e2 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....f148b3f7ff76822b87760b13cc1915e2 |
| قاعدة البيانات: |
OpenAIRE |