Epidemiological studies on dengue virus type 3 in Playa municipality, Havana, Cuba, 2001–2002

التفاصيل البيبلوغرافية
العنوان: Epidemiological studies on dengue virus type 3 in Playa municipality, Havana, Cuba, 2001–2002
المؤلفون: Susana Vázquez, Annia Gonzalez, María G. Guzmán, Ángel M. Álvarez, Mayling Alvarez, Rosmari Rodríguez, Luis Morier, Dydie Ruiz, Alequis Pavón, Guillermo Cruz, Scott B. Halstead, Gustavo Kourí, Otto Peláez, Delfina Rosario
المصدر: International Journal of Infectious Diseases. 16(3):e198-e203
بيانات النشر: Elsevier BV, 2012.
سنة النشر: 2012
مصطلحات موضوعية: Adult, Male, Serotype, Microbiology (medical), medicine.medical_specialty, Adolescent, Epidemiology, Secondary infection, viruses, Pathogenesis, Dengue virus, medicine.disease_cause, Disease Outbreaks, Dengue fever, Dengue, Young Adult, medicine, Humans, Severe Dengue, Serotyping, Child, Aged, Retrospective Studies, Aged, 80 and over, Coinfection, business.industry, Outbreak, virus diseases, Cuba, General Medicine, Dengue Virus, Middle Aged, medicine.disease, Antibodies, Neutralizing, Virology, Confidence interval, Epidemiologic Studies, Dengue virus type 3, Infectious Diseases, Child, Preschool, Cohort, Dengue hemorrhagic fever, Female, business
الوصف: Summary Objectives Recognizing the uniqueness of secondary dengue virus (DENV)-1/3 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) cases at an interval of 24 years, we sought to estimate DENV infections as well as the ratios between mild disease and DHF/DSS by DENV infection sequence in Playa District (Havana, Cuba) during the 2001–2002 outbreak of dengue virus type 3 (DENV-3). Methods A retrospective seroepidemiological study was conducted in 2003 in Playa District. Blood samples were collected from a 1% random sample of residents and were studied for the prevalence of dengue neutralizing antibodies. Results DENV-3 was found to have infected 7.2% (95% confidence interval (95% CI) 6.0–8.4%) of susceptible individuals (the entire cohort), the majority of whom experienced silent infections. Virtually every individual who had a secondary infection in the sequence DENV-1 then DENV-3 became ill, with a ratio of severe to mild cases of 1:35 (95% CI 1:67–1:23). Secondary infections in the sequence DENV-2/3 were less pathogenic than DENV-1/3. Mild disease accompanying secondary DENV2/3 occurred at a ratio of 1:4.49 infections (95% CI 1:5.77–1:3.42) secondary infections. Conclusions The results obtained highlight the role of the infecting serotype and also the sequence of the viral infection in the clinical outcome of a dengue infection.
تدمد: 1201-9712
DOI: 10.1016/j.ijid.2011.09.026
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10bbc9ee059b3e9c94d536893aed10d
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....f10bbc9ee059b3e9c94d536893aed10d
قاعدة البيانات: OpenAIRE
الوصف
تدمد:12019712
DOI:10.1016/j.ijid.2011.09.026