Self-assembling Molecular Medicine for the Subacute Phase of Ischemic Stroke
| العنوان: | Self-assembling Molecular Medicine for the Subacute Phase of Ischemic Stroke |
|---|---|
| المؤلفون: | Takahiro Muraoka, Itsuki Ajioka |
| المصدر: | Neurochemical Research. 47:2488-2498 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cellular and Molecular Neuroscience, Tissue Engineering, Humans, Molecular Medicine, Hydrogels, General Medicine, Peptides, Regenerative Medicine, Biochemistry, Extracellular Matrix, Ischemic Stroke |
| الوصف: | Ischemic stroke leads to acute neuron death and forms an injured core, triggering delayed cell death at the penumbra. The impaired brain functions after ischemic stroke are hardly recovered because of the limited regenerative properties. However, recent rodent intervention studies manipulating the extracellular environments at the subacute phase shed new light on the regenerative potency of the injured brain. This review introduces the rational design of artificial extracellular matrix (ECM) mimics using supramolecular peptidic scaffolds, which self-assemble via non-covalent bonds and form hydrogels. The facile customizability of the peptide structures allows tuning the hydrogels' physical and biochemical properties, such as charge states, hydrophobicity, cell adhesiveness, stiffness, and stimuli responses. Supramolecular peptidic materials can create safer and more economical drugs than polymer materials and cell transplantation. We also discuss the importance of activating developmental programs for the recovery at the subacute phase of ischemic stroke. Self-assembling molecular medicine mimicking the ECMs and activating developmental programs may stand as a new drug modality of regenerative medicine in various tissues. |
| تدمد: | 1573-6903 0364-3190 |
| DOI: | 10.1007/s11064-022-03638-5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cf1ecdc0e271714f695e9ae9a865da https://doi.org/10.1007/s11064-022-03638-5 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f0cf1ecdc0e271714f695e9ae9a865da |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15736903 03643190 |
|---|---|
| DOI: | 10.1007/s11064-022-03638-5 |