Brain anticonvulsant protection of mice given chronic carbamazepine under various fatty acid and magnesium diet conditions

التفاصيل البيبلوغرافية
العنوان: Brain anticonvulsant protection of mice given chronic carbamazepine under various fatty acid and magnesium diet conditions
المؤلفون: Pierre Maurois, Nicole Pages, Bernadette Delplanque, Pierre Bac, Joseph Vamecq
المصدر: Prostaglandins, leukotrienes, and essential fatty acids. 87(2-3)
سنة النشر: 2012
مصطلحات موضوعية: medicine.medical_specialty, food.ingredient, N-Methylaspartate, medicine.medical_treatment, Clinical Biochemistry, Drug Administration Schedule, Epilepsy, Reflex, Mice, food, Seizures, Internal medicine, Fatty Acids, Omega-6, Fatty Acids, Omega-3, medicine, Weaning, Animals, Magnesium, Unsaturated fatty acid, chemistry.chemical_classification, Arachidonic Acid, Sunflower oil, food and beverages, Fatty acid, Brain, Cell Biology, Carbamazepine, Diet, Ethosuximide, Anticonvulsant, Endocrinology, chemistry, Biochemistry, Phenobarbital, Phenytoin, lipids (amino acids, peptides, and proteins), Anticonvulsants, Female, Magnesium Deficiency, medicine.drug, Polyunsaturated fatty acid, Signal Transduction
الوصف: The anticonvulsant and mood stabilizer drug carbamazepine (CBZ) was evaluated for anti-seizure activity after drug pretreatment of young weaning mice given various oil-based diets. These diets had various mono-(MUFA) and poly-(PUFA) unsaturated fatty acid contents, were associated or not with magnesium deprivation, and were given over the entire experimental period (34 days). The diets included a commercial and three purified synthetic diets (n-6 PUFA, n-3 PUFA and MUFA-based chows containing 5% corn/sunflower oils 1:3, 5% rapeseed oil and 5% high oleic acid sunflower oil/sunflower oil 7:3, respectively). A 10-days CBZ treatment (50mg/kg/day fragmented in two daily intraperitoneal injections of 25mg/kg) was given 20 days after initiating diet administration and evaluations of mice was performed 4 days after arrest of CBZ in various seizure tests. In these conditions, CBZ pretreatment still exhibited anticonvulsant protection especially in magnesium-deficient animals. Ethosuximide (ESM)-like profiles under MUFA and n-3 PUFA diets and unusual GABA A ergic profile under n-6 PUFA diet in magnesium-deficiency dependent audiogenic seizures (MDDAS) test as well as protection against NMDA-induced seizures in all lipid (n-3 PUFA>MUFA and n-6 PUFA) diet conditions were observed in CBZ-pretreated mice. By highlighting ESM-like and anti-NMDA mechanisms previously induced by an n-3 PUFA diet, present CBZ anticonvulsant properties suggest brain protective targets common to CBZ and n-3 PUFAs.
تدمد: 1532-2823
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef26af153a6f99ebc92ffda502f4383b
https://pubmed.ncbi.nlm.nih.gov/22749692
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....ef26af153a6f99ebc92ffda502f4383b
قاعدة البيانات: OpenAIRE