Are the innate and adaptive immune systems setting hypertension on fire?
| العنوان: | Are the innate and adaptive immune systems setting hypertension on fire? |
|---|---|
| المؤلفون: | Fernanda Luciano Rodrigues, Gisele Facholi Bomfim, Fernando S. Carneiro |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Elsevier BV, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, HIPERTENSÃO, Chemokine, Antigen-Presenting Cells, Inflammation, Adaptive Immunity, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Animals, Humans, Pharmacology, Innate immune system, biology, Innate lymphoid cell, CCL18, Pattern recognition receptor, Acquired immune system, Immunity, Innate, 030104 developmental biology, Hypertension, Immunology, biology.protein, medicine.symptom |
| الوصف: | Hypertension is the most common chronic cardiovascular disease and is associated with several pathological states, being an important cause of morbidity and mortality around the world. Low-grade inflammation plays a key role in hypertension and the innate and adaptive immune systems seem to contribute to hypertension development and maintenance. Hypertension is associated with vascular inflammation, increased vascular cytokines levels and infiltration of immune cells in the vasculature, kidneys and heart. However, the mechanisms that trigger inflammation and immune system activation in hypertension are completely unknown. Cells from the innate immune system express pattern recognition receptors (PRR), which detect conserved pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) that induce innate effector mechanisms to produce endogenous signals, such as inflammatory cytokines and chemokines, to alert the host about danger. Additionally, antigen-presenting cells (APC) act as sentinels that are activated by PAMPs and DAMPs to sense the presence of the antigen/neoantigen, which ensues the adaptive immune system activation. In this context, different lymphocyte types are activated and contribute to inflammation and end-organ damage in hypertension. This review will focus on experimental and clinical evidence demonstrating the contribution of the innate and adaptive immune systems to the development of hypertension. |
| تدمد: | 1043-6618 |
| DOI: | 10.1016/j.phrs.2017.01.010 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef01aab7cc53a1d31584f158f6232470 https://doi.org/10.1016/j.phrs.2017.01.010 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ef01aab7cc53a1d31584f158f6232470 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10436618 |
|---|---|
| DOI: | 10.1016/j.phrs.2017.01.010 |