14-3-3γ Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors
| العنوان: | 14-3-3γ Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors |
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| المؤلفون: | Jae Yong Park, Eun Mi Hwang, Do Eon Kim, Osung Kwon, Kyoung Mi Sim, Hyung-Wook Kim, Chang Hoon Cho |
| المصدر: | Experimental Neurobiology |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Disease, 14-3-3γ, Anxiety, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Internal medicine, Medicine, ADHD, YWHAG, Acute stress, business.industry, Heterozygote advantage, Ywhag, Pathophysiology, Hyperactivity, 030104 developmental biology, Endocrinology, Knockout mouse, Original Article, Neurology (clinical), medicine.symptom, Haploinsufficiency, business, 030217 neurology & neurosurgery |
| الوصف: | 14-3-3γ plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3γ is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3γ deficiency are largely unknown. Here, by using 14-3-3γ deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3γ heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3γ levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3γ heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms. Graphical Abstract |
| تدمد: | 1226-2560 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee162dd426cf86f95416959179eb7fc https://pubmed.ncbi.nlm.nih.gov/30853823 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eee162dd426cf86f95416959179eb7fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 12262560 |
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