Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition
| العنوان: | Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition |
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| المؤلفون: | Seung Taik Lim, Joo Yeon Hong, Seul-Ki Kim, Dong Keon Kweon, Eun Hee Jang, Dong Hwa Cho |
| المصدر: | Food Sci Biotechnol |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0106 biological sciences, Materials science, Composite number, macromolecular substances, Oral cavity, 01 natural sciences, Applied Microbiology and Biotechnology, Article, law.invention, chemistry.chemical_compound, 0404 agricultural biotechnology, Magazine, law, 010608 biotechnology, Ultimate tensile strength, Hyaluronic acid, medicine, technology, industry, and agriculture, Pullulan, 04 agricultural and veterinary sciences, 040401 food science, Carboxymethyl cellulose, chemistry, Chemical engineering, Elongation, Food Science, Biotechnology, medicine.drug |
| الوصف: | Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF. |
| تدمد: | 2092-6456 1226-7708 |
| DOI: | 10.1007/s10068-020-00771-1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec250135fe16da6d912726dc5416c48 https://doi.org/10.1007/s10068-020-00771-1 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eec250135fe16da6d912726dc5416c48 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20926456 12267708 |
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| DOI: | 10.1007/s10068-020-00771-1 |