Cellular Immune Responses in Seronegative Sexual Contacts of Acute Hepatitis C Patients
| العنوان: | Cellular Immune Responses in Seronegative Sexual Contacts of Acute Hepatitis C Patients |
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| المؤلفون: | Ashraf Amin, Betty H. Robertson, Margaret James Koziel, Camilla S. Graham, Qi He, Sanaa M. Kamal, Mohamed A. Madwar, Ahmed Al Tawil, Tatsunori Nakano, Jens Rasenack, Alaa M. Ismail |
| المصدر: | Journal of Virology. 78:12252-12258 |
| بيانات النشر: | American Society for Microbiology, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, CD4-Positive T-Lymphocytes, Male, Cellular immunity, Sexual Behavior, Immunology, Viremia, Biology, Lymphocyte Activation, Microbiology, Interferon-gamma, Immune system, Virology, medicine, Humans, Seroconversion, ELISPOT, virus diseases, Hepatitis C, Hepatitis C Antibodies, medicine.disease, digestive system diseases, Insect Science, Acute Disease, biology.protein, Pathogenesis and Immunity, Female, Viral disease, Antibody, T-Lymphocytes, Cytotoxic |
| الوصف: | Acute hepatitis C virus (HCV) is typically defined as new viremia and antibody seroconversion. Rates and immunologic correlates of hepatitis C clearance have therefore been based on clearance of viremia only in individuals who initially had an antibody response. We sought to characterize the immunological correlates of clearance in patients with acute hepatitis C and their sexual contacts. We prospectively determined CD4+and CD8+cytotoxic T-lymphocyte responses in index patients with acute HCV and their sexual contacts who developed acute infection, either with or without spontaneous clearance, as well as those contacts who never developed viremia. Responses were measured using proliferation and ELISpot assays for CD4+and CD8+responses. We demonstrate in this prospective study that cellular immune responses can develop in exposed but persistently aviremic and antibody-negative individuals as well as those individuals with spontaneous clearance of acute HCV. These findings lend further credence to the importance of cellular immune responses in recovery from HCV and suggest that low exposure to HCV may lead to development of HCV-specific immune responses without ongoing HCV replication. This finding has important implications for HCV vaccine and therapeutic development. |
| تدمد: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.78.22.12252-12258.2004 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec0a5460f28d62b5dd5194c436475d0 https://doi.org/10.1128/jvi.78.22.12252-12258.2004 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eec0a5460f28d62b5dd5194c436475d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10985514 0022538X |
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| DOI: | 10.1128/jvi.78.22.12252-12258.2004 |