The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis
| العنوان: | The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis |
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| المؤلفون: | Ninke Leffers, Marloes J. M. Gooden, Hans W. Nijman, Toos Daemen, de Truuske Bock |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Pathology, Colorectal cancer, LEUKOCYTE INFILTRATION, chemical and pharmacologic phenomena, Biology, COLORECTAL-CANCER, Lymphocytes, Tumor-Infiltrating, LUNG-CANCER, Neoplasms, HEPATOCELLULAR-CARCINOMA, Internal medicine, EPITHELIAL OVARIAN-CANCER, medicine, Humans, Epithelial ovarian cancer, REGULATORY T-CELLS, Lung cancer, Molecular Diagnostics, tumour-infiltrating lymphocytes, ANTIGEN-PROCESSING MACHINERY, Tumor-infiltrating lymphocytes, Cancer, hemic and immune systems, medicine.disease, meta-analysis, MHC CLASS-I, IMMUNE CELLS, Neoplasms diagnosis, Hepatocellular carcinoma, Meta-analysis, prognosis, GASTRIC-CANCER |
| الوصف: | BACKGROUND: Tumour- infiltrating lymphocytes (TILs) are often found in tumours, presumably reflecting an immune response against the tumour. We carried out a systematic review and meta-analysis, aiming to establish pooled estimates for survival outcomes based on the presence of TILs in cancer. METHODS: A Pubmed and Embase literature search was designed. Studies were included, in which the prognostic significance of intratumoural CD3+, CD4+, CD8+, and FoxP3+ lymphocytes, as well as ratios between these subsets, were determined in solid tumours. RESULTS: In pooled analysis, CD3+ TILs had a positive effect on survival with a hazard ratio (HR) of 0.58 (95% confidence interval (CI) 0.43-0.78) for death, as did CD8+ TILs with a HR of 0.71 (95% CI 0.62-0.82). FoxP3+ regulatory TILs were not linked to overall survival, with a HR of 1.19 (95% CI 0.84-1.67). The CD8/FoxP3 ratio produced a more impressive HR (risk of death: HR 0.48, 95% CI 0.34-0.68), but was used in relatively few studies. Sample size and follow-up time seemed to influence study outcomes. CONCLUSION: Any future studies should be carefully designed, to prevent overestimating the effect of TILs on prognosis. In this context, ratios between TIL subsets may be more informative. British Journal of Cancer (2011) 105, 93-103. doi:10.1038/bjc.2011.189 www.bjcancer.com Published online 31 May 2011 (C) 2011 Cancer Research UK |
| تدمد: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2011.189 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9a73221d528f9f6bb30ee2b908413f https://doi.org/10.1038/bjc.2011.189 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ee9a73221d528f9f6bb30ee2b908413f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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| DOI: | 10.1038/bjc.2011.189 |