Temporal expression patterns of distinct cytokines and M1/M2 macrophage polarization regulate rheumatoid arthritis progression
| العنوان: | Temporal expression patterns of distinct cytokines and M1/M2 macrophage polarization regulate rheumatoid arthritis progression |
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| المؤلفون: | Hsu Shan Huang, Shih Ping Dai, Hao Chiang, Chia Chi Kung, Wei Hsin Sun |
| المصدر: | Molecular Biology Reports. 47:3423-3437 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_treatment, Anti-Inflammatory Agents, Gene Expression, Pain, Inflammation, Arthritis, Rheumatoid, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Genetics, medicine, Animals, Interleukin 6, Molecular Biology, Cells, Cultured, Autoimmune disease, Mice, Inbred ICR, biology, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Macrophages, Interleukin-17, Chronic pain, General Medicine, medicine.disease, M2 Macrophage, Synoviocytes, 030104 developmental biology, Cytokine, 030220 oncology & carcinogenesis, Rheumatoid arthritis, Immunology, biology.protein, Cytokines, medicine.symptom, Transcriptome, business |
| الوصف: | Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovial joints and often associated with chronic pain. Chronic joint inflammation is attributed to severe proliferation of synoviocytes and resident macrophages and infiltration of immune cells. These cells secrete pro-inflammatory cytokines such as tumor necrosis factor α (TNF-α), interleukin 6 (IL-6) and IL-17 to overcome actions of anti-inflammatory cytokines, thereby maintaining chronic inflammation and pain. The imbalance between pro-inflammatory cytokines (produced by M1 macrophages) and anti-inflammatory cytokines (produced by M2 macrophages) is a feature of RA progression, but the switch time of M1/M2 polarization and which receptor regulates the switch remain unsolved. Here we used an established RA mouse model to demonstrate that TNF-α expression was responsible for the initial acute stage of inflammation and pain (1-4 weeks), IL-17 expression the transition stage (4-12 weeks), and IL-6 expression the later maintenance stage (> 12 weeks). The switch time of M1/M2 polarization occurred at 4-8 weeks. We also identified a potential compound, anthra[2,1-c][1,2,5] thiadiazole-6,11-dione (NSC745885), that specifically inhibited T-cell death-associated gene 8 (TDAG8) function and expression. NSC745885 decreased joint inflammation and destruction and attenuated pain by reducing cytokine production and regulating the M1/M2 polarization switch. TDAG8 may participate in regulating the M1/M2 polarization and temporal expression of distinct cytokines to control RA progression. |
| تدمد: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-020-05422-6 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5b8052c2971eb540db01bdf15f640d https://doi.org/10.1007/s11033-020-05422-6 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ee5b8052c2971eb540db01bdf15f640d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734978 03014851 |
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| DOI: | 10.1007/s11033-020-05422-6 |