التفاصيل البيبلوغرافية
| العنوان: |
Does chloroquine really act through oxidative stress? |
| المؤلفون: |
Donatella Taramelli, Erica Pasini, Piero Olliaro, Nicoletta Basilico, Silvia Parapini, Diego Monti |
| المصدر: |
FEBS Letters. (1-3):3-5 |
| بيانات النشر: |
Federation of European Biochemical Societies. Published by Elsevier B.V. |
| مصطلحات موضوعية: |
Erythrocytes, Nitrogen, Radical, Plasmodium falciparum, Biophysics, chemistry.chemical_element, Pharmacology, medicine.disease_cause, Biochemistry, Oxygen, chemistry.chemical_compound, Antimalarials, Structural Biology, Chloroquine, parasitic diseases, Genetics, medicine, Animals, Humans, Carbon monoxide, Molecular Biology, biology, Molecular Structure, Chemistry, Cell Biology, Hb - Hemoglobin, Carbon Dioxide, biology.organism_classification, Malaria, Oxidative Stress, Carboxyhemoglobin, Molecular oxygen, Oxidative stress, medicine.drug |
| الوصف: |
To assess whether molecular oxygen and oxidative stress contribute to chloroquine activity, we cultivated strains of Plasmodium falciparum in erythrocytes with carboxyhemoglobin and an atmosphere containing 2% CO, 5% CO 2 and 93% N 2 . Results indicate that, contrary to common belief, oxygen is not involved in the activity of chloroquine. Reactive radicals formation is suggested. |
| اللغة: |
English |
| تدمد: |
0014-5793 |
| DOI: |
10.1016/S0014-5793(02)02881-8 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eddb2595a42e700eed0112dceacc95e4 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....eddb2595a42e700eed0112dceacc95e4 |
| قاعدة البيانات: |
OpenAIRE |