An endogenous aryl hydrocarbon receptor ligand enhances de novo generation of regulatory T cells in humans
| العنوان: | An endogenous aryl hydrocarbon receptor ligand enhances de novo generation of regulatory T cells in humans |
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| المؤلفون: | Nadia Belhadj Hmida, Imen Zamali, Raja Rekik, Ons Kammoun, Ahlem Ben Hmid, Melika Ben Ahmed, Mohamed-Ridha Barbouche |
| المساهمون: | Laboratoire d'immunologie clinique [Institut Pasteur de Tunis], Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Laboratoire de Transmission, Contrôle et Immunobiologie des Infections - Laboratory of Transmission, Control and Immunobiology of Infection (LR11IPT02), Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM) |
| المصدر: | Journal of Leukocyte Biology Journal of Leukocyte Biology, Society for Leukocyte Biology, 2018, ⟨10.1002/JLB.2AB0518-205RR⟩ |
| بيانات النشر: | HAL CCSD, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Indoles, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Immunology, Endogeny, Biology, Ligands, T-Lymphocytes, Regulatory, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Immunology and Allergy, Receptor, Transcription factor, ComputingMilieux_MISCELLANEOUS, Cell Biology, Immunotherapy, Aryl hydrocarbon receptor, Ligand (biochemistry), 3. Good health, Cell biology, Thiazoles, 030104 developmental biology, Receptors, Aryl Hydrocarbon, chemistry, 030220 oncology & carcinogenesis, Toxicity, biology.protein, Xenobiotic |
| الوصف: | The aromatic hydrocarbons receptor (AhR) is a ligand-dependent transcription factor that plays a role in mediating toxicity to xenobiotics. Its key role in immune regulation has been recently demonstrated. Recent data pointed to the efficacy of ITE (2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester), a nontoxic ligand of AhR, in experimental models of inflammatory diseases. Such effect was mainly through the expansion of regulatory T cells (Tregs). Similarly, TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin), a toxic ligand of AhR, has been shown to exert comparable effects on Tregs in mice. Herein, we showed that ITE has no effects on natural Tregs. However, it supports the de novo generation of Tregs in humans while promoting their suppressive functions. Our data bring new elements supporting the use of ITE in human therapy of inflammatory diseases. ITE, a non-toxic endogenous aryl hydrocarbon receptor ligand, enhances de novo generation of regulatory T cells in humans and promotes their suppressive functions. |
| اللغة: | English |
| تدمد: | 0741-5400 |
| DOI: | 10.1002/JLB.2AB0518-205RR⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed375ae88e76228eacba4973237b952e https://hal-riip.archives-ouvertes.fr/pasteur-01946445 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ed375ae88e76228eacba4973237b952e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 07415400 |
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| DOI: | 10.1002/JLB.2AB0518-205RR⟩ |