Atrial Natriuretic Peptide mRNA in Patients With Heart Disease
| العنوان: | Atrial Natriuretic Peptide mRNA in Patients With Heart Disease |
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| المؤلفون: | Thomas Fischer, Rudolf E. Lang, Rainer Dietz, Markus Haass, Jörg Hänze, Werner Saggau |
| المصدر: | American Journal of Hypertension. 3:234-236 |
| بيانات النشر: | Oxford University Press (OUP), 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Heart Diseases, Heart disease, medicine.medical_treatment, Hemodynamics, Blood Pressure, Atrial natriuretic peptide, Internal medicine, medicine.artery, Internal Medicine, medicine, Humans, Heart Atria, RNA, Messenger, Aged, Cardiac catheterization, business.industry, Venous Plasma, Middle Aged, medicine.disease, NPR2, Cardiac surgery, Pulmonary artery, cardiovascular system, Cardiology, Female, business, Atrial Natriuretic Factor, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology |
| الوصف: | The regulation of atrial natriuretic peptide (ANP) synthesis within cardiac atrial myocytes was investigated in 8 patients undergoing cardiac surgery (valve replacement or coronary bypass graft). Hemodynamic data were obtained during cardiac catheterization and venous plasma samples for ANP were withdrawn prior to surgery. Probes for determination of tissue ANP levels and ANPmRNA concentrations were taken from the right atrium. Both plasma ANP (r = 0.75; P less than .05) and ANPmRNA (r = 0.86; P less than .01) were closely related to mean pulmonary artery pressure. ANPmRNA was also related to plasma ANP (r = 0.60; P less than .07). However, no significant relationships were obtained between either plasma ANP or ANPmRNA and right atrial ANP concentrations. These data suggest that right atrial ANP synthesis is regulated by cardiac filling pressures and possibly by plasma ANP levels, independent from corresponding ANP tissue concentrations. |
| تدمد: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/3.3.234 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd306d63833b15059b69dfddb1e13a4 https://doi.org/10.1093/ajh/3.3.234 |
| رقم الانضمام: | edsair.doi.dedup.....ecd306d63833b15059b69dfddb1e13a4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19417225 08957061 |
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| DOI: | 10.1093/ajh/3.3.234 |