Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging
| العنوان: | Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging |
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| المؤلفون: | Calvin J. Yoon, Yong Song Gho, Sekyu Hwang, Bumju Kim, Peter T. C. So, Yeoreum Yoon, Jun Ho Lee, Sungjee Kim, Gilgu Lee, Taejun Wang, Myoung Joon Kim, Viet-Hoan Le, Seunghun Lee, Myoung Ho Jang, Ki Hean Kim, Won Hyuk Jang, Seoyeon Bok, G-One Ahn, Jaewook Lee, Euiheon Chung, Seung-Jae Myung, Chun-Pyo Hong |
| المساهمون: | Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, So, Peter T. C. |
| المصدر: | Scientific Reports SCIENTIFIC REPORTS(6) |
| بيانات النشر: | Nature Publishing Group, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Pathology, medicine.medical_specialty, Moxifloxacin, Urinary Bladder, Contrast Media, Endogeny, Article, Cornea, 03 medical and health sciences, Mice, 0302 clinical medicine, Microscopy, Intestine, Small, medicine, Animals, Humans, Tissue Distribution, Cytotoxicity, Skin, Multidisciplinary, Chemistry, Fluorescence, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Microscopy, Fluorescence, Multiphoton, Cell culture, Biophysics, NIH 3T3 Cells, HT29 Cells, 030217 neurology & neurosurgery, Intracellular, medicine.drug, Fluoroquinolones |
| الوصف: | Multiphoton microscopy (MPM) is a nonlinear fluorescence microscopic technique widely used for cellular imaging of thick tissues and live animals in biological studies. However, MPM application to human tissues is limited by weak endogenous fluorescence in tissue and cytotoxicity of exogenous probes. Herein, we describe the applications of moxifloxacin, an FDA-approved antibiotic, as a cell-labeling agent for MPM. Moxifloxacin has bright intrinsic multiphoton fluorescence, good tissue penetration and high intracellular concentration. MPM with moxifloxacin was demonstrated in various cell lines, and animal tissues of cornea, skin, small intestine and bladder. Clinical application is promising since imaging based on moxifloxacin labeling could be 10 times faster than imaging based on endogenous fluorescence. David H. Koch Institute for Integrative Cancer Research at MIT (Bridge Initiative) |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| DOI: | 10.1038/srep27142 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb5066c261590f72e0cd985320faed5 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ecb5066c261590f72e0cd985320faed5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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| DOI: | 10.1038/srep27142 |