التفاصيل البيبلوغرافية
| العنوان: |
RIP4 Is an Ankyrin Repeat-Containing Kinase Essential for Keratinocyte Differentiation |
| المؤلفون: |
J.Greg Murison, Annjanette S. Warren, Timothy A. Bird, Jonathan M.J. Derry, Keith Charrier, Moira Glaccum, Pamela M. Holland, Suzanne Kanaly, Jacques J. Peschon, Cynthia R. Willis, G. Duke Virca |
| المصدر: |
Current Biology. 12(16):1424-1428 |
| بيانات النشر: |
Elsevier BV, 2002. |
| سنة النشر: |
2002 |
| مصطلحات موضوعية: |
Keratinocytes, Cellular differentiation, Cell, Protein Serine-Threonine Kinases, Biology, General Biochemistry, Genetics and Molecular Biology, Mice, Keratin, medicine, Animals, Homeostasis, Oligonucleotide Array Sequence Analysis, Mice, Knockout, chemistry.chemical_classification, Mucous Membrane, integumentary system, Agricultural and Biological Sciences(all), Kinase, Biochemistry, Genetics and Molecular Biology(all), Proteins, Mucous membrane, Cell Differentiation, Anatomy, Molecular biology, Epithelium, Mice, Inbred C57BL, Phenotype, medicine.anatomical_structure, Epidermal Cells, chemistry, Apoptosis, Receptor-Interacting Protein Serine-Threonine Kinases, Keratins, Female, Epidermis, General Agricultural and Biological Sciences, Protein Kinases |
| الوصف: |
The epidermis is a stratified, continually renewing epithelium dependent on a balance among cell proliferation, differentiation, and death for homeostasis. In normal epidermis, a mitotically active basal layer gives rise to terminally differentiating keratinocytes that migrate outward and are ultimately sloughed from the skin surface as enucleated squames. Although many proteins are known to function in maintaining epidermal homeostasis, the molecular coordination of these events is poorly understood [1, 2]. RIP4 is a novel RIP (receptor-interacting protein) family kinase with ankyrin repeats cloned from a keratinocyte cDNA library. RIP4 deficiency in mice results in perinatal lethality associated with abnormal epidermal differentiation. The phenotype of RIP4−/− mice in part resembles that of mice lacking IKKα, a component of a complex that regulates NF-kappaB [3–5]. Despite the similar keratinocyte defects in RIP4- and IKKα-deficient mice, these kinases function in distinct pathways. RIP4 functions cell autonomously within the keratinocyte lineage. Unlike IKKα, RIP4-deficient skin fails to fully differentiate when grafted onto a normal host [6]. Instead, abnormal hair follicle development and epidermal dysplasia, indicative of progression into a more pathologic state, are observed. Thus, RIP4 is a critical component of a novel pathway that controls keratinocyte differentiation. |
| تدمد: |
0960-9822 |
| DOI: |
10.1016/s0960-9822(02)01075-8 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8fa09bb2a7b4f62e905e680dcb88dc |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....ec8fa09bb2a7b4f62e905e680dcb88dc |
| قاعدة البيانات: |
OpenAIRE |