Role of oxidative stress in carbon nanotube-generated health effects
| العنوان: | Role of oxidative stress in carbon nanotube-generated health effects |
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| المؤلفون: | Ditte Marie Jensen, Yi Cao, Pernille Høgh Danielsen, Daniel Vest Christophersen, Steffen Loft, Henrik Klingberg, Peter Møller, Jette Gjerke Hemmingsen, Nicklas Raun Jacobsen, Martin Roursgaard, Ali Kermanizadeh, Lars-Georg Hersoug, Kim Jantzen |
| المصدر: | Archives of Toxicology. 88:1939-1964 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Lung Diseases, Antioxidant, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Pharmacology, Toxicology, medicine.disease_cause, Antioxidants, Superoxide dismutase, Lipid peroxidation, chemistry.chemical_compound, medicine, Animals, Humans, Nanotechnology, Cardiopulmonary disease, Inflammation, chemistry.chemical_classification, Reactive oxygen species, biology, Nanotubes, Carbon, General Medicine, Glutathione, Oxidative Stress, chemistry, Biochemistry, Cardiovascular Diseases, Catalase, biology.protein, Lipid Peroxidation, Reactive Oxygen Species, Oxidative stress, DNA Damage |
| الوصف: | The development of products containing carbon nanotubes (CNTs) is a major achievement of nanotechnology, although concerns regarding risk of toxic effects linger if the hazards associated with these materials are not thoroughly investigated. Exposure to CNTs has been associated with depletion of antioxidants, increased intracellular production of reactive oxygen species and pro-inflammatory signaling in cultured cells with primary function in the immune system as well as epithelial, endothelial and stromal cells. Pre-treatment with antioxidants has been shown to attenuate these effects, indicating a dependency of oxidative stress on cellular responses to CNT exposure. CNT-mediated oxidative stress in cell cultures has been associated with elevated levels of lipid peroxidation products and oxidatively damaged DNA. Investigations of oxidative stress endpoints in animal studies have utilized pulmonary, gastrointestinal, intravenous and intraperitoneal exposure routes, documenting elevated levels of lipid peroxidation products and oxidatively damaged DNA nucleobases especially in the lungs and liver, which to some extent occur concomitantly with altered levels of components in the antioxidant defense system (glutathione, superoxide dismutase or catalase). CNTs are biopersistent high aspect ratio materials, and some are rigid with lengths that lead to frustrated phagocytosis and pleural accumulation. There is accumulating evidence showing that pulmonary exposure to CNTs is associated with fibrosis and neoplastic changes in the lungs, and cardiovascular disease. As oxidative stress and inflammation responses are implicated in the development of these diseases, converging lines of evidence indicate that exposure to CNTs is associated with increased risk of cardiopulmonary diseases through generation of a pro-inflammatory and pro-oxidant milieu in the lungs. |
| تدمد: | 1432-0738 0340-5761 |
| DOI: | 10.1007/s00204-014-1356-x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb32af965c1759f1d81eb053489a8b89 https://doi.org/10.1007/s00204-014-1356-x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....eb32af965c1759f1d81eb053489a8b89 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320738 03405761 |
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| DOI: | 10.1007/s00204-014-1356-x |