Plasma endotoxin concentration and endotoxin binding capacity of plasma acute phase proteins in cirrhotics with variceal bleeding: An analysis by new methods
| العنوان: | Plasma endotoxin concentration and endotoxin binding capacity of plasma acute phase proteins in cirrhotics with variceal bleeding: An analysis by new methods |
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| المؤلفون: | Tadasu Tsujii, M Matsumoto, Shigenobu Tsujita, Masahiko Matsumura, Hideyuki Kojima, Akira Takaya, Hiroshi Fukui |
| المصدر: | Journal of Gastroenterology and Hepatology. 9:582-586 |
| بيانات النشر: | Wiley, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Liver Cirrhosis, medicine.medical_specialty, Pathology, Time Factors, Cirrhosis, Alpha (ethology), Esophageal and Gastric Varices, Gastroenterology, Internal medicine, Blood plasma, medicine, Humans, chemistry.chemical_classification, Varix, Hepatology, biology, business.industry, Haptoglobin, Acute-phase protein, medicine.disease, Endotoxins, Chromogenic Compounds, chemistry, Transferrin, biology.protein, Gastrointestinal Hemorrhage, business, Varices, Acute-Phase Proteins |
| الوصف: | Plasma endotoxin levels in 12 cirrhotics with bleeding from oesophageal varices and 50 cirrhotics without bleeding were measured by the chromogenic assay after the pretreatment of sample by perchloric acid (HClO4) and triethylamine. Endotoxin in cirrhotics with bleeding from varices was significantly higher than those without bleeding. In patients with bleeding, endotoxin increased for 3 days after the bleeding, first in the supernatant fraction and then in the precipitate fraction by HClO4 treatment. Peak plasma alpha 1-acid glycoprotein and haptoglobin were observed 3 days after the bleeding. Alpha 1-antitrypsin gradually increased for 14 days. Transferrin did not markedly change. The endotoxin-binding capacity of transferrin and alpha 1-acid glycoprotein increased immediately after bleeding and thereafter decreased, but that of alpha 1-antitrypsin tended to increase in the recovery period. In summary, the plasma endotoxin concentration and endotoxin-binding capacity of alpha 1-acid glycoprotein and transferrin were shown to have increased after bleeding from varices by this new method. There may be a close relationship between endotoxaemia and acute phase reaction in this situation. |
| تدمد: | 1440-1746 0815-9319 |
| DOI: | 10.1111/j.1440-1746.1994.tb01565.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1fb8591259501b1e144a6ed424d9bc https://doi.org/10.1111/j.1440-1746.1994.tb01565.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....eb1fb8591259501b1e144a6ed424d9bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401746 08159319 |
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| DOI: | 10.1111/j.1440-1746.1994.tb01565.x |