Rosmarinic Acid Inhibits Platelet Aggregation and Neointimal Hyperplasia In Vivo and Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration In Vitro via Activation of the Keap1-Nrf2-ARE Antioxidant System
| العنوان: | Rosmarinic Acid Inhibits Platelet Aggregation and Neointimal Hyperplasia In Vivo and Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration In Vitro via Activation of the Keap1-Nrf2-ARE Antioxidant System |
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| المؤلفون: | Chen Chen, Jiulong Ma, Zhiping Xu, Liang Chen, Bo Sun, Yan Shi, Yujia Miao, Tianlong Wu, Meng Qin, Yang Zhang, Ming Zhang, Xia Cao |
| المصدر: | Journal of Agricultural and Food Chemistry. 70:7420-7440 |
| بيانات النشر: | American Chemical Society (ACS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Hyperplasia, Kelch-Like ECH-Associated Protein 1, Platelet Aggregation, NF-E2-Related Factor 2, Myocytes, Smooth Muscle, Becaplermin, General Chemistry, Cell Dedifferentiation, Vascular Remodeling, Depsides, Antioxidant Response Elements, Antioxidants, Muscle, Smooth, Vascular, Cell Movement, Cinnamates, Neointima, Humans, General Agricultural and Biological Sciences, Cells, Cultured, Cell Proliferation |
| الوصف: | The activation of platelets and proliferation of vascular smooth muscle cells (VSMCs) in the vascular intima play an essential role in the pathological mechanism of vascular restenosis (RS). Rosmarinic acid (RA) is a natural phenolic acid compound. However, its mechanism of action on platelets and VSMCs is still unclear. This study investigated the effects of RA on platelet function, VSMCs phenotypic conversion, proliferation, and migration in vascular remodeling with a specific focus on the Keap1-Nrf2-ARE signaling pathway. RA inhibited platelet aggregation and Ca |
| تدمد: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.2c01176 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb18b3aef8dcb5b39a714ab9f7f31b92 https://doi.org/10.1021/acs.jafc.2c01176 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....eb18b3aef8dcb5b39a714ab9f7f31b92 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205118 00218561 |
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| DOI: | 10.1021/acs.jafc.2c01176 |