Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock
| العنوان: | Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock |
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| المؤلفون: | CardShock Study Investigators, Toni Jäntti, Tuija Javanainen, Tuukka Tarvasmäki, Heli Tolppanen, Veli-Pekka Harjola, Bruno Levy, Kai C. Wollert, Kari Pulkki, Anu Holopainen, Anu Kataja, Johan Lassus, Alexandre Mebazaa, Raija Jurkko, Mari Hongisto, Antoine Kimmoun, Alessandro Sionis |
| المساهمون: | HUS Emergency Medicine and Services, Department of Diagnostics and Therapeutics, University of Helsinki, Clinicum, HUS Heart and Lung Center, Kardiologian yksikkö, Department of Medicine |
| المصدر: | JOURNAL OF CARDIAC FAILURE r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| بيانات النشر: | CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Growth Differentiation Factor 15, Internationality, Shock, Cardiogenic, growth differentiation factor 15 (GDF-15), 030204 cardiovascular system & hematology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, AGE, Risk Factors, Internal medicine, SCORE, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Mortality, Cardiogenic shock, Acidosis, Aged, UTILITY, Aged, 80 and over, Framingham Risk Score, Plasma samples, business.industry, biomarkers, ASSOCIATION, Middle Aged, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, CHRONIC HEART-FAILURE, INSIGHTS, 3121 General medicine, internal medicine and other clinical medicine, Risk stratification, embryonic structures, Hyperlactatemia, Female, GDF15, prognosis, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Perfusion, Biomarkers |
| الوصف: | Background: The aim of this study was to assess the levels, kinetics, and prognostic value of growth differentiation factor 15 (GDF-15) in cardiogenic shock (CS). Methods and Results: Levels of GDF-15 were determined in serial plasma samples (0-120 h) from 177 CS patients in the CardShock study. Kinetics of GDF-15, its association with 90-day mortality, and incremental value for risk stratification were assessed. The median GDF-15(0h) level was 9647 ng/L (IQR 4500-19,270 ng/L) and levels above median were significantly associated with acidosis, hyperlactatemia, renal dysfunction, and higher 90-day mortality (56% vs 28%, P7000 ng/L was identified as a strong predictor of death (OR 5.0; 95% CI 1.9-3.8, P=.002). Adding GDF-15(12h) >7000 ng/L to the CardShock risk score improved discrimination and risk stratification for 90-day mortality. Conclusions: GDF-15 levels are highly elevated in CS and associated with markers of systemic hypoperfusion and end-organ dysfunction. GDF-15 helps to discriminate survivors from non-survivors very early in CS. |
| تدمد: | 1071-9164 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb05f9a10bb46a2e1beca0c8b4ecaf90 https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2355 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eb05f9a10bb46a2e1beca0c8b4ecaf90 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10719164 |
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