التفاصيل البيبلوغرافية
| العنوان: |
Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites |
| المؤلفون: |
Pia Vahteristo, Minna Allinen, Kirsi Syrjäkoski, Robert Winqvist, Tommi Kainu, K Vähäkangas, Pia Huusko, Heli Nevanlinna, Olli Kallioniemi, Hannaleena Eerola, Katrin Rapakko |
| المصدر: |
British Journal of Cancer |
| بيانات النشر: |
Springer Science and Business Media LLC, 2001. |
| سنة النشر: |
2001 |
| مصطلحات موضوعية: |
Cancer Research, endocrine system diseases, Tumor suppressor gene, Short Communication, Mammary gland, Breast Neoplasms, Biology, medicine.disease_cause, Germline, Conserved sequence, Cohort Studies, Germline mutation, Breast cancer, Neoplastic Syndromes, Hereditary, medicine, Humans, Li-Fraumeni syndrome, skin and connective tissue diseases, neoplasms, Conserved Sequence, Finland, Germ-Line Mutation, Genetics, Mutation, TP53 mutations, hereditary breast cancer, Genes, p53, medicine.disease, Pedigree, medicine.anatomical_structure, Oncology, Li–Fraumeni syndrome, Female, Tumor Suppressor Protein p53 |
| الوصف: |
We have screened for germline TP53 mutations in Finnish BRCA1 and BRCA2 mutation-negative families. This study represents the largest survey of the entire protein-encoding portion of TP53, and indicates that mutations are only found at conserved domains in breast cancer families also meeting the criteria for Li-Fraumeni/Li-Fraumeni-like syndrome, explaining only a very small additional fraction of the hereditary breast cancer cases. © 2001 Cancer Research Campaign http://www.bjcancer.com |
| تدمد: |
1532-1827 |
| DOI: |
10.1054/bjoc.2000.1530 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa757dc91c699d526599c0b94978240
https://doi.org/10.1054/bjoc.2000.1530 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....eaa757dc91c699d526599c0b94978240 |
| قاعدة البيانات: |
OpenAIRE |