Repurposing Clinically Approved Drugs for the Treatment of Bacillus cereus, a Surrogate for Bacillus anthracis
| العنوان: | Repurposing Clinically Approved Drugs for the Treatment of Bacillus cereus, a Surrogate for Bacillus anthracis |
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| المؤلفون: | Alan Hernandez, Alexy Jabbour, Masami Amakawa, Anastasia Levitin, Soneli Gunawardana, Mikhail Martchenko Shilman, Chase Pasos, Saleem Alameh |
| المصدر: | ACS Omega ACS Omega, Vol 5, Iss 34, Pp 21929-21939 (2020) |
| بيانات النشر: | American Chemical Society, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | biology, business.industry, General Chemical Engineering, fungi, Bacillus cereus, Virulence, General Chemistry, biology.organism_classification, Article, Bacillus anthracis, Microbiology, Chemistry, Effective treatment, Medicine, Anthrax disease, business, QD1-999, Repurposing |
| الوصف: | Of the numerous infectious diseases afflicting humans, anthrax disease, caused by Bacillus anthracis, poses a major threat in its virulence and lack of effective treatment. The currently lacking standards of care, as well as the lengthy drug approval process, demonstrate the pressing demand for treatment for B. anthracis infections. The present study screened 1586 clinically approved drugs in an attempt to identify repurposable compounds against B. cereus, a relative strain that shares many physical and genetic characteristics with B. anthracis. Our study yielded five drugs that successfully inhibited B. cereus growth: dichlorophen, oxiconazole, suloctidil, bithionol, and hexestrol. These drugs exhibited varying levels of efficacy in broad-spectrum experiments against several Gram-positive and Gram-negative bacterial strains, with hexestrol showing the greatest inhibition across all tested strains. Through tests for the efficacy of each drug on B. cereus, bithionol was the single most potent compound on both solid and liquid media and exhibited even greater eradication of B. cereus in combination with suloctidil on solid agar. This multifaceted in vitro study of approved drugs demonstrates the potential to repurpose these drugs as treatments for anthrax disease in a time-efficient manner to address a global health need. |
| اللغة: | English |
| تدمد: | 2470-1343 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6aee4ea1453d46f3bd418838b3bfc5 http://europepmc.org/articles/PMC7469645 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ea6aee4ea1453d46f3bd418838b3bfc5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24701343 |
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