An electron microscopic and biochemical study of the effects of glucagon on glycogen autophagy in the liver and heart of newborn rats
| العنوان: | An electron microscopic and biochemical study of the effects of glucagon on glycogen autophagy in the liver and heart of newborn rats |
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| المؤلفون: | O. B. Kotoulas, Stefanos A. Kalamidas, D.J. Kondomerkos |
| المصدر: | Microscopy Research and Technique. 63:87-93 |
| بيانات النشر: | Wiley, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | medicine.medical_specialty, Time Factors, Histology, Vacuole, Biology, Glucagon, Glucosidases/metabolism, chemistry.chemical_compound, Glycogen/*metabolism, Heart/drug effects/physiology, Internal medicine, Autophagy, medicine, Animals, Maltose, Instrumentation, Electron microscopic, Myocardium/*metabolism/ultrastructure, Protein Synthesis Inhibitors, chemistry.chemical_classification, Liver/drug effects/*metabolism/ultrastructure, Glycogen, Myocardium, Maltose/metabolism, Heart, Autophagy/*drug effects, Glucagon/*pharmacology, Rats, Cardiovascular physiology, Microscopy, Electron, Medical Laboratory Technology, Endocrinology, Enzyme, Animals, Newborn, Liver, chemistry, Hepatocytes/drug effects/metabolism/ultrastructure, Protein Synthesis Inhibitors/*pharmacology, Hepatocytes, Ultrastructure, Anatomy, Glucosidases |
| الوصف: | The effects of glucagon on the ultrastructural appearance and acid glucosidase activities in the liver and heart of newborn rats were studied. Liver or heart glycogen-hydrolyzing activity of acid glucosidase increased 3 hours after birth and gradually decreased from 3 to 9 hours. Maltose-hydrolyzing activity of acid glucosidase also rose 3 hours after birth, maintained a plateau between 3 and 6 hours, and fell at 9 hours. The administration of glucagon increased autophagic activity in the hepatocytes at the age of 6 hours. Glycogen inside the autophagic vacuoles was decreased, apparently due to the increased glycogen degradation. Glycogen-hydrolyzing activity was elevated in both the liver and the heart. Maltose-hydrolyzing activity was elevated in the liver, but not in the heart. The results of this study suggest that the glycogen-hydrolyzing and maltose-hydrolyzing activities of acid glucosidase are due to different enzymes. Glucagon's effect on the glycogen-hydrolyzing acid glucosidase activity and autophagosomal morphology is similar in both the liver and the heart. Microsc Res Tech |
| تدمد: | 1097-0029 1059-910X |
| DOI: | 10.1002/jemt.20000 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5e4f19fab8f6f448be282e56827532 https://doi.org/10.1002/jemt.20000 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ea5e4f19fab8f6f448be282e56827532 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970029 1059910X |
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| DOI: | 10.1002/jemt.20000 |