Significance of MPV, RDW and PDW with the Severity and Mortality of COVID-19 and Effects of Acetylsalicylic Acid Use
| العنوان: | Significance of MPV, RDW and PDW with the Severity and Mortality of COVID-19 and Effects of Acetylsalicylic Acid Use |
|---|---|
| المؤلفون: | Selim Aydemir, Remziye Doğan, Emrah Aksakal, Oktay Gulcu, Sidar Şiyar Aydın, Hilal Erken Pamukcu, İbrahim Saraç, Ibrahim Halil Tanboga, Kamuran Kalkan, Faruk Aydınyılmaz |
| المصدر: | Clinical and Applied Thrombosis/Hemostasis, Vol 27 (2021) Clinical and Applied Thrombosis/Hemostasis |
| بيانات النشر: | SAGE Publishing, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Blood Platelets, Erythrocyte Indices, Male, medicine.medical_specialty, Erythrocytes, Time Factors, red cell distribution width, Original Manuscript, Gastroenterology, Severity of Illness Index, law.invention, law, Predictive Value of Tests, Internal medicine, Severity of illness, medicine, platelet distribution width, Humans, Diseases of the circulatory (Cardiovascular) system, Hospital Mortality, Mean platelet volume, Aged, Retrospective Studies, Aged, 80 and over, Aspirin, mean platelet volume, business.industry, Platelet Distribution Width, COVID-19, Anticoagulants, Red blood cell distribution width, Hematology, General Medicine, Middle Aged, Intensive care unit, COVID-19 Drug Treatment, Treatment Outcome, Predictive value of tests, RC666-701, Platelet aggregation inhibitor, Female, business, Platelet Aggregation Inhibitors, medicine.drug |
| الوصف: | We aimed to investigate association between mean platelet volume (MVP), platelet distribution width (PDW) and red cell distribution width (RDW) and mortality in patients with COVID-19 and find out in which patients the use of acetylsalicylic acid (ASA) affects the prognosis due to the effect of MPV on thromboxan A2. A total of 5142 patients were divided into those followed in the intensive care unit (ICU) and those followed in the ward. Patient medical records were examined retrospectively. ROC analysis showed that the area under curve (AUC) values were 0.714, 0.750, 0.843 for MPV, RDW and D-Dimer, the cutoff value was 10.45fl, 43.65fl, 500.2 ng/mL respectively. (all P 10.45 f/l and D-Dimer >500.2 ng/mL, treatment with ASA had lower in-hospital and 180-day mortality than patients without ASA in ICU patients (HR = 0.773; 95% CI = 0.595-0.992; P = .048, HR = 0.763; 95% CI = 0.590-0.987; P = .036). Administration of low-dose ASA in addition to anti-coagulant according to MPV and D-dimer levels reduces mortality. |
| اللغة: | English |
| تدمد: | 1938-2723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea21a2c03675b44d58dcfcc2377e69bb https://doaj.org/article/617aceddaa7b4abe9d94cd871f581e8a |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ea21a2c03675b44d58dcfcc2377e69bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19382723 |
|---|