Deep-Sea Anemones Are Prospective Source of New Antimicrobial and Cytotoxic Compounds
| العنوان: | Deep-Sea Anemones Are Prospective Source of New Antimicrobial and Cytotoxic Compounds |
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| المؤلفون: | Stanislav D. Anastyuk, Irina Gladkikh, M. V. Pivkin, Aleksandra Kvetkina, Kozlovskaya Emma P, E. V. Kostina, Ekaterina A. Yurchenko, I. A. Bakunina, Marina Isaeva, Margarita Monastyrnaya, Pavel S. Dmitrenok, Victoria Chausova, Roman S. Popov, Elena Leychenko |
| المصدر: | Marine Drugs, Vol 19, Iss 654, p 654 (2021) Marine Drugs Marine Drugs; Volume 19; Issue 12; Pages: 654 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Aquatic Organisms, Antifungal Agents, enzyme-inhibitory activity, QH301-705.5, Stomphia coccinea, Pharmaceutical Science, tentacle extracts, Antineoplastic Agents, Bacillus subtilis, medicine.disease_cause, Gram-Positive Bacteria, Article, Microbiology, Russia, sea anemone toxins, Peptide mass fingerprinting, Cell Line, Tumor, Candida albicans, Drug Discovery, medicine, Animals, hemolytic activity, Biology (General), Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Corallimorpharia, antimicrobial activity, biology, Chemistry, antifungal activity, Antimicrobial, biology.organism_classification, Actiniaria, cytotoxicity, Actinostola, Anti-Bacterial Agents, Sea Anemones, Staphylococcus aureus, Marine Toxins, Bacteria |
| الوصف: | The peculiarities of the survival and adaptation of deep-sea organisms raise interest in the study of their metabolites as promising drugs. In this work, the hemolytic, cytotoxic, antimicrobial, and enzyme-inhibitory activities of tentacle extracts from five species of sea anemones (Cnidaria, orders Actiniaria and Corallimorpharia) collected near the Kuril and Commander Islands of the Far East of Russia were evaluated for the first time. The extracts of Liponema brevicorne and Actinostola callosa demonstrated maximal hemolytic activity, while high cytotoxic activity against murine splenocytes and Ehrlich carcinoma cells was found in the extract of Actinostola faeculenta. The extracts of Corallimorphus cf. pilatus demonstrated the greatest activity against Ehrlich carcinoma cells but were not toxic to mouse spleen cells. Sea anemones C. cf. pilatus and Stomphia coccinea are promising sources of antimicrobial and antifungal compounds, being active against Gram-positive bacteria Bacillus subtilis, Staphylococcus aureus, and yeast Candida albicans. Moreover, all sea anemones contain α-galactosidase inhibitors. Peptide mass fingerprinting of L. brevicorne and C. cf. pilatus extracts provided a wide range of peptides, predominantly with molecular masses of 4000–5900 Da, which may belong to a known or new structural class of toxins. The obtained data allow concluding that deep-sea anemones are a promising source of compounds for drug discovery. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1660-3397 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea00492908239a0bd567013f7244b80a https://www.mdpi.com/1660-3397/19/12/654 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ea00492908239a0bd567013f7244b80a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16603397 |
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