Underlying dimensions of the EORTC QLQ-C30 in a Cuban population of patients with advanced non-small cell lung cancer
| العنوان: | Underlying dimensions of the EORTC QLQ-C30 in a Cuban population of patients with advanced non-small cell lung cancer |
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| المؤلفون: | Javier Ballesteros, M. Alvarez, Martha Fors, Bárbara Wilkinson, Carmen Viada, Camilo Rodríguez, Tania Crombet, Carlos N. Bouza, Lázara García, Aliuska Frías |
| المصدر: | Quality of Life Research. 29:3441-3448 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Lung Neoplasms, Population, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Carcinoma, Non-Small-Cell Lung, Item response theory, otorhinolaryngologic diseases, medicine, Humans, Lung cancer, education, education.field_of_study, 030503 health policy & services, Eortc qlq c30, Public Health, Environmental and Occupational Health, Cuba, social sciences, medicine.disease, humanities, Confirmatory factor analysis, Clinical trial, 030220 oncology & carcinogenesis, Quality of Life, Female, Non small cell, 0305 other medical science, Psychology, Clinical psychology |
| الوصف: | Quality of Life Core Questionnaire of the European Organization for the Research and Treatment of Cancer (EORTC QLQ-C30) is one of the most used quality of life questionnaires in cancer studies. It provides scores for five functional scales, nine symptom scales, and two single items which assess overall health status and quality of life. However, high correlations among QLQ-C30 items suggest a reduced dimensionality for the scale. To assess the dimensionality of the EORTC QLQ-C30 using item response theory (IRT) in a training sample and confirmatory factor analysis (CFA) in a test sample. We analyzed responses to QLQ-C30 from 1,107 patients with advanced lung cancer who were included in five clinical trials of immunotherapy. We used non-parametric and parametric IRT models (Mokken, and Samejima's graded response) in a random training set (n = 332) for initial assessment of dimensions and item characteristics of the QLQ-C30. Finally, we used CFA in the test set (n = 775) to confirm the measurement domains. Mokken model showed that QLQ-C30 fits a unidimensional scale, whereas Samejima model showed that most QLQ-C30 items present adequate difficulty and discrimination. All items showed adequate scalability indexes with an overall scalability of 0.47 (medium scale). The QLQ-C30-reduced dimensionality was confirmed by CFA (comparative fit index = 0.98, root mean square error of approximation = 0.055) with all items presenting factorial loadings > 0.40. The EORTC QLQ-C30 fits a unidimensional latent construct identified with perceived quality of life in advanced lung cancer patients. RPCEC00000161, RPCEC00000181 and RPCEC00000205 |
| تدمد: | 1573-2649 0962-9343 |
| DOI: | 10.1007/s11136-020-02584-5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9883b1e396900d256420ed077f38442 https://doi.org/10.1007/s11136-020-02584-5 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e9883b1e396900d256420ed077f38442 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15732649 09629343 |
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| DOI: | 10.1007/s11136-020-02584-5 |