The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
| العنوان: | The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability |
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| المؤلفون: | Joyce M. Sherman, Jef D. Boeke, Elizabeth E. Cameron, Scott E. Devine, Carrie Baker Brachmann, Lorraine Pillus |
| المصدر: | Genes & Development. 9:2888-2902 |
| بيانات النشر: | Cold Spring Harbor Laboratory, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Saccharomyces cerevisiae Proteins, Transcription, Genetic, Ultraviolet Rays, RNA-induced silencing complex, Genes, Fungal, Molecular Sequence Data, Fibroblast Growth Factor 4, Gene Dosage, Saccharomyces cerevisiae, Biology, Gene dosage, Histone Deacetylases, Conserved sequence, Sirtuin 2, Sirtuin 1, Proto-Oncogene Proteins, Genetics, Transcriptional regulation, Animals, Humans, Sirtuins, Gene silencing, Gene family, Amino Acid Sequence, Conserved Sequence, Silent Information Regulator Proteins, Saccharomyces cerevisiae, Regulation of gene expression, Sequence Homology, Amino Acid, Cell Cycle, Temperature, Telomere, Argonaute, DNA-Binding Proteins, Fibroblast Growth Factors, Gene Expression Regulation, Mutation, Trans-Activators, Chromosomes, Fungal, Sequence Alignment, Developmental Biology |
| الوصف: | Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is known about conserved mechanisms of silencing. We report here the discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacteria to mammals. At least three HST genes can function in silencing; HST1 overexpression restores transcriptional silencing to a sir2 mutant and hst3 hst4 double mutants are defective in telomeric silencing. In addition, HST3 and HST4 together contribute to proper cell cycle progression, radiation resistance, and genomic stability, establishing new connections between silencing and these fundamental cellular processes. |
| تدمد: | 1549-5477 0890-9369 |
| DOI: | 10.1101/gad.9.23.2888 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94988e494b0e62fac931b253cbaa972 https://doi.org/10.1101/gad.9.23.2888 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e94988e494b0e62fac931b253cbaa972 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15495477 08909369 |
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| DOI: | 10.1101/gad.9.23.2888 |