التفاصيل البيبلوغرافية
العنوان:
Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate
المؤلفون:
Chris English , Marian R. Fairgrieve , J. Christopher Gatenby , Gwenn A. Garden , Sean Merillat , Jeff Thiel , Robert F. Hevner , Jason Ogle , Wonsok Lee , Erica Boldenow , Colin Studholme , Lakshmi Rajagopal , Jay Vornhagen , Michael S. Diamond , Blair Armistead , Michael Gale , Dennis W. W. Shaw , Raj P. Kapur , Michael Davis , G. Michael Gough , William B. Dobyns , Todd L. Richards , Jennifer E. Stencel-Baerenwald , Audrey Baldessari , Kristina M. Adams Waldorf , La Rene Kuller , Richard Green , Sandra E. Juul , Richard Grant , Manjiri Dighe , Elyse C. Dewey , Jennifer Tisoncik-Go
المصدر:
Nature medicine . 22(11)
سنة النشر:
2016
مصطلحات موضوعية:
0301 basic medicine , Pathology , medicine.medical_specialty , Magnetic Resonance Spectroscopy , Glutamine , Glutamic Acid , Autopsy , Biology , General Biochemistry, Genetics and Molecular Biology , Ultrasonography, Prenatal , Article , Zika virus , Choline , 03 medical and health sciences , Fetus , Pregnancy , medicine , Animals , Pregnancy Complications, Infectious , Aspartic Acid , medicine.diagnostic_test , Zika Virus Infection , Brain , Magnetic resonance imaging , General Medicine , Pigtail macaque , Zika Virus , biology.organism_classification , Creatine , Echoencephalography , Magnetic Resonance Imaging , 030104 developmental biology , Gliosis , Cerebral white matter hypoplasia , RNA, Viral , Female , medicine.symptom , Macaca nemestrina , Inositol
الوصف:
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.
تدمد:
1546-170X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91d8d61d9191f1c91b0bfb91524f66c https://pubmed.ncbi.nlm.nih.gov/27618651
Rights:
OPEN
رقم الانضمام:
edsair.doi.dedup.....e91d8d61d9191f1c91b0bfb91524f66c
قاعدة البيانات:
OpenAIRE