Associations between cardiovascular disease risk factors and IL-6 and hsCRP levels in the elderly

التفاصيل البيبلوغرافية
العنوان: Associations between cardiovascular disease risk factors and IL-6 and hsCRP levels in the elderly
المؤلفون: Jerzy Chudek, Andrzej Wiecek, Krystyna Kozakiewicz, Michał Skrzypek, Paweł Nadrowski, Tomasz Grodzicki, Monika Puzianowska-Kuźnicka, Małgorzata Mossakowska, Tomasz Zdrojewski
المصدر: Experimental Gerontology. 85:112-117
بيانات النشر: Elsevier BV, 2016.
سنة النشر: 2016
مصطلحات موضوعية: Male, Aging, medicine.medical_specialty, 030204 cardiovascular system & hematology, Overweight, Logistic regression, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Risk Factors, Internal medicine, Genetics, medicine, Humans, Obesity, cardiovascular diseases, Interleukin 6, Geriatric Assessment, Molecular Biology, Depression (differential diagnoses), Aged, Aged, 80 and over, Inflammation, biology, Interleukin-6, business.industry, Cholesterol, HDL, Smoking, nutritional and metabolic diseases, Cell Biology, Statin treatment, medicine.disease, C-Reactive Protein, Logistic Models, Cardiovascular Diseases, Multivariate Analysis, Disease risk, biology.protein, Female, Poland, Hydroxymethylglutaryl-CoA Reductase Inhibitors, medicine.symptom, business, Biomarkers, 030217 neurology & neurosurgery, Kidney disease
الوصف: Background Age-related diseases, including cardiovascular diseases (CVD) may be stimulated by microinflammation, marked by increased level of IL-6 and high-sensitivity CRP (hsCRP). We aimed to investigate whether aging “per se” independently contributes to the microinflammation, in addition to traditional and novel CVD risk factors. Methods/results The research sample included 4979 participants from PolSenior Study, aged over 65 years. The study consisted of three visits and included questionnaire survey, geriatric assessment and blood/urine sampling in 4101 participants (83.2% of the sample). Serum hsCRP and plasma IL-6 were measured in 4093 (99.8%) and 3895 (95.0%) subjects. Multiple logistic regression showed that advanced age (over 80 years), obesity, actual/former smoking, decreased HDL-cholesterol, chronic kidney disease (CKD) and depression were associated with occurrence of increased level of IL-6 (> 2.4 pg/ml). For hsCRP we found that advanced age, overweight/obesity, decreased HDL-cholesterol, actual/former smoking and CKD were associated with increased level of hsCRP (> 3 mg/l), while high income and statins treatment were related to lower level of hsCRP. Conclusions Microinflammation in the elderly is not fully explained by traditional and novel CVD risk factors. Active smoking, obesity and low HDL-cholesterol among traditional risk factors, along with CKD, depression and low income among novel risk factors, are the strongest determinants of microinflammation. Also we found that statin therapy decreases hsCRP levels, which indicates a potential role of inflammation in CVD as a target for intervention in the elderly (e.g. statin use).
تدمد: 0531-5565
DOI: 10.1016/j.exger.2016.10.001
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e2702880ece9fef9668e6fdd432d4a
https://doi.org/10.1016/j.exger.2016.10.001
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....e8e2702880ece9fef9668e6fdd432d4a
قاعدة البيانات: OpenAIRE
الوصف
تدمد:05315565
DOI:10.1016/j.exger.2016.10.001