Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse
| العنوان: | Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse |
|---|---|
| المؤلفون: | Gillian M. Griffiths, Christian M. Gawden-Bone |
| المساهمون: | Gawden-Bone, Christian [0000-0003-0413-3727], Griffiths, Gillian [0000-0003-0434-5842], Apollo - University of Cambridge Repository |
| المصدر: | Frontiers in Immunology, Vol 10 (2019) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media S.A., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, lcsh:Immunologic diseases. Allergy, Immunological Synapses, diacylglycerol (DAG), phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3), Immunology, T cells, Review, Cytoplasmic Granules, Immunological synapse, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, cytotoxic T lymphocytes (CTLs), Extracellular, Humans, Immunology and Allergy, Cilia, Cytoskeleton, skin and connective tissue diseases, Actin, phospholipids, Diacylglycerol kinase, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), Phosphatidic acid, Phosphatidylserine, Actins, 3. Good health, Cell biology, 030104 developmental biology, chemistry, Second messenger system, sense organs, lcsh:RC581-607, Metabolic Networks and Pathways, Signal Transduction, T-Lymphocytes, Cytotoxic, 030215 immunology |
| الوصف: | Phosphoinositides, together with the phospholipids phosphatidylserine and phosphatidic acid, are important components of the plasma membrane acting as second messengers that, with diacylglycerol, regulate a diverse range of signalling events converting extracellular changes into cellular responses. Local changes in their distribution and membrane charge on the inner leaflet of the plasma membrane play important roles in immune cell function. Here we discuss their distribution and regulators highlighting the importance of membrane changes across the immune synapse on the cytoskeleton and the impact on the function of cytotoxic T lymphocytes. |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document; image/tiff |
| اللغة: | English |
| تدمد: | 1664-3224 |
| DOI: | 10.3389/fimmu.2019.00700/full |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fc6013501a0a6459d63ae242cc8af4 https://www.frontiersin.org/article/10.3389/fimmu.2019.00700/full |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e7fc6013501a0a6459d63ae242cc8af4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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| DOI: | 10.3389/fimmu.2019.00700/full |