Is poor neonatal adaptation after exposure to antidepressant medication related to fetal cortisol levels? An explorative study
| العنوان: | Is poor neonatal adaptation after exposure to antidepressant medication related to fetal cortisol levels? An explorative study |
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| المؤلفون: | Noera Kieviet, Silke de Groot, Adriaan Honig, Yolanda B. de Rijke, Elisabeth F.C. van Rossum, Erica L T van den Akker, Koert M. Dolman, Gerard Noppe |
| المساهمون: | EMGO - Mental health, Rehabilitation medicine, Psychiatry, Internal Medicine, Clinical Chemistry, Pediatrics |
| المصدر: | Early Human Development, 98, 37-43. Elsevier Ireland Ltd Kieviet, N, de Groot, S, Noppe, G, de Rijke, Y B, van Rossum, E F C, van den Akker, E L T, Dolman, K M & Honig, A 2016, ' Is poor neonatal adaptation after exposure to antidepressant medication related to fetal cortisol levels? An explorative study ', Early Human Development, vol. 98, pp. 37-43 . https://doi.org/10.1016/j.earlhumdev.2016.06.005 |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Hydrocortisone, Hospital Anxiety and Depression Scale, Noradrenergic and specific serotonergic antidepressant, 03 medical and health sciences, Child Development, Sex Factors, 0302 clinical medicine, Pregnancy, Internal medicine, medicine, Humans, Fetus, musculoskeletal, neural, and ocular physiology, Infant, Newborn, Case-control study, Obstetrics and Gynecology, Gestational age, medicine.disease, Adaptation, Physiological, Antidepressive Agents, 030227 psychiatry, Endocrinology, Case-Control Studies, Prenatal Exposure Delayed Effects, biological sciences, Pediatrics, Perinatology and Child Health, cardiovascular system, Etiology, Female, Psychology, tissues, 030217 neurology & neurosurgery, Hair, medicine.drug |
| الوصف: | Background As a marker for poor neonatal adaptation (PNA) is lacking, the diagnostic process is difficult and includes invasive additional testing. Aims In order to develop a marker, it is essential to gain insight into the etiology of PNA. We hypothesized that the fetal cortisol level may play a role in this etiology. Study design Non-randomized, prospective controlled study. Outcome measures We examined hair cortisol levels of infants exposed and not exposed to selective antidepressants (SADs) during pregnancy. These cortisol levels represent the mean cortisol level during the last trimester of pregnancy. Infants exposed to SADs who developed PNA according to the pediatrician (PNA +, n = 25), infants exposed to SADs who did not develop PNA (PNA −, n = 40) and infants not exposed to SADs (controls, n = 105) were compared. Results In infants with PNA, hair cortisol levels were higher compared to infants without PNA. However this difference was only statistically significant in female infants (girls B0.33, p = 0.04, boys B0.05, p = 0.82). There was no correlation between nonspecific distress, measured by the Finnegan score and fetal hair cortisol levels (B-0.15, p = 0.30). All analyses were adjusted for type of delivery and gestational age. Conclusions Our results suggest that the hypothalamic pituitary adrenal (HPA) axis activity may play a sex-specific role in the development of PNA. As PNA is most likely of a multifactorial origin, it would be interesting to examine other factors possibly involved in the etiology of PNA in future studies, such as (epi) genetics. |
| اللغة: | English |
| تدمد: | 0378-3782 |
| DOI: | 10.1016/j.earlhumdev.2016.06.005 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72bc05d2cd3d630d831c55c5df81470 https://research.vumc.nl/en/publications/d0bfe113-5ba4-4dac-9752-8ef177b5803d |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....e72bc05d2cd3d630d831c55c5df81470 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03783782 |
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| DOI: | 10.1016/j.earlhumdev.2016.06.005 |