240‐week entecavir maleate treatment in Chinese chronic hepatitis B predominantly genotype B or C
| العنوان: | 240‐week entecavir maleate treatment in Chinese chronic hepatitis B predominantly genotype B or C |
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| المؤلفون: | Jing‐Hang Xu, Ya‐Nan Fan, Yan‐Yan Yu, Chong‐Wen Si, Zheng Zeng, Zhong‐Nan Xu, Jun Li, Qing Mao, Da‐Zhi Zhang, Hong Tang, Ji‐Fang Sheng, Xin‐Yue Chen, Qin Ning, Guang‐Feng Shi, Qing Xie, Xi‐Quan Zhang, Jun Dai |
| المصدر: | Journal of Viral Hepatitis. 29:862-867 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | China, Hepatitis B virus, Guanine, Genotype, Hepatology, Maleates, Antiviral Agents, Hepatitis B, Chronic, Treatment Outcome, Infectious Diseases, Virology, DNA, Viral, Humans, Hepatitis B e Antigens |
| الوصف: | This study aimed to evaluate the efficacy and safety of entecavir(ETV) versus ETV maleate in Chinese patients with chronic hepatitis B(CHB). This was a randomized, double-blind, double-dummy, controlled, multicentre study. Patients were randomly assigned to receive 48 weeks of treatment with 0.5 mg/day ETV (group A) or 0.5 mg/day ETV maleate (group B), then, all patients received treatment with 0.5 mg/day ETV maleate from week 49 onwards. Patients were regularly followed up. Serum hepatitis B virus (HBV) markers were detected. Adverse events (AE) were recorded. The primary endpoint was the decline in HBV DNA in each group at the end of treatment. Secondary endpoints included the rate of HBV DNA below the lower limit of detection (LLOD) (20 I U/ml) at the end of treatment, the rate of hepatitis B e antigen (HBeAg) loss, the rate of HBeAg seroconversion and serum alanine aminotransferase (ALT) normalization. One hundred and thirty-seven (71 in group A) patients with HBeAg-positive CHB and 46 (21 in group A) patients with HBeAg-negative CHB completed the 240-week treatment and follow-up. Baseline characteristics were well balanced between the two groups. For the HBeAg-positive CHB patients, the mean HBV DNA level had similarly decreased from baseline in both groups (A: by 6.67 log |
| تدمد: | 1365-2893 1352-0504 |
| DOI: | 10.1111/jvh.13724 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c28033cab9eaa487db0abe0f7a546c https://doi.org/10.1111/jvh.13724 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e6c28033cab9eaa487db0abe0f7a546c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652893 13520504 |
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| DOI: | 10.1111/jvh.13724 |