Prediction of Long-Term Treatment Response to Selective Serotonin Reuptake Inhibitors (SSRIs) Using Scalp and Source Loudness Dependence of Auditory Evoked Potentials (LDAEP) Analysis in Patients with Major Depressive Disorder
| العنوان: | Prediction of Long-Term Treatment Response to Selective Serotonin Reuptake Inhibitors (SSRIs) Using Scalp and Source Loudness Dependence of Auditory Evoked Potentials (LDAEP) Analysis in Patients with Major Depressive Disorder |
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| المؤلفون: | Seung Hwan Lee, Young-Min Park, Miseon Shim, Bun-Hee Lee |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 16, Iss 3, Pp 6251-6265 (2015) Volume 16 Issue 3 Pages 6251-6265 |
| بيانات النشر: | MDPI, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, standardized low resolution brain electromagnetic tomography (sLORETA), loudness dependence of auditory evoked potentials (LDAEP), Electroencephalography, Serotonergic, Catalysis, Article, Inorganic Chemistry, lcsh:Chemistry, Internal medicine, medicine, Escitalopram, Humans, Physical and Theoretical Chemistry, Psychiatry, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Sertraline, Depressive Disorder, Major, response, Scalp, medicine.diagnostic_test, major depressive disorder, business.industry, Organic Chemistry, Beck Depression Inventory, General Medicine, Middle Aged, medicine.disease, Paroxetine, Antidepressive Agents, Computer Science Applications, serotonin, lcsh:Biology (General), lcsh:QD1-999, antidepressants, Cardiology, Evoked Potentials, Auditory, Major depressive disorder, Antidepressant, Female, business, Selective Serotonin Reuptake Inhibitors, medicine.drug |
| الوصف: | Background: Animal and clinical studies have demonstrated that the loudness dependence of auditory evoked potentials (LDAEP) is inversely related to central serotonergic activity, with a high LDAEP reflecting weak serotonergic neurotransmission and vice versa, though the findings in humans have been less consistent. In addition, a high pretreatment LDAEP appears to predict a favorable response to antidepressant treatments that augment the actions of serotonin. The aim of this study was to test whether the baseline LDAEP is correlated with response to long-term maintenance treatment in patients with major depressive disorder (MDD). Methods: Scalp N1, P2 and N1/P2 LDAEP and standardized low resolution brain electromagnetic tomography-localized N1, P2, and N1/P2 LDAEP were evaluated in 41 MDD patients before and after they received antidepressant treatment (escitalopram (n = 32, 10.0 ± 4.0 mg/day), sertraline (n = 7, 78.6 ± 26.7 mg/day), and paroxetine controlled-release formulation (n = 2, 18.8 ± 8.8 mg/day)) for more than 12 weeks. A treatment response was defined as a reduction in the Beck Depression Inventory (BDI) score of > 50% between baseline and follow-up. Results: The responders had higher baseline scalp P2 and N1/P2 LDAEP than nonresponders (p = 0.017 p = 0.036). In addition, changes in total BDI score between baseline and follow-up were larger in subjects with a high baseline N1/P2 LDAEP than those with a low baseline N1/P2 LDAEP (p = 0.009). There were significantly more responders in the high-LDAEP group than in the low-LDAEP group (p = 0.041). Conclusions: The findings of this study reveal that a high baseline LDAEP is associated with a clinical response to long-term antidepressant treatment. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a5e47ec6b0136487e5c61a11aaeddb http://europepmc.org/articles/PMC4394530 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e6a5e47ec6b0136487e5c61a11aaeddb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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