Hybrid organosilicon/polyol phantom for photoacoustic imaging
| العنوان: | Hybrid organosilicon/polyol phantom for photoacoustic imaging |
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| المؤلفون: | Roberto Pini, Fulvio Ratto, Claudia Borri, Giada Magni, Marina Mazzoni, Sonia Centi, Lucia Cavigli |
| المصدر: | Biomedical optics express 10 (2019): 3719–3730. doi:10.1364/BOE.10.003719 info:cnr-pdr/source/autori:Ratto, Fulvio; Cavigli, Lucia; Borri, Claudia; Centi, Sonia; Magni, Giada; Mazzoni, Marina; Pini, Roberto/titolo:Hybrid organosilicon%2Fpolyol phantom for photoacoustic imaging/doi:10.1364%2FBOE.10.003719/rivista:Biomedical optics express/anno:2019/pagina_da:3719/pagina_a:3730/intervallo_pagine:3719–3730/volume:10 |
| بيانات النشر: | Optical Society of America, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Scanner, Materials science, Photoacoustic, 01 natural sciences, Imaging phantom, Phantoms, Article, 010309 optics, 03 medical and health sciences, chemistry.chemical_compound, Optics, Speed of sound, 0103 physical sciences, Medical imaging, Image resolution, Biomedical optics, 030304 developmental biology, 0303 health sciences, Polydimethylsiloxane, business.industry, Atomic and Molecular Physics, and Optics, chemistry, Attenuation coefficient, business, Acoustic attenuation, Biotechnology |
| الوصف: | The rapid development of hardware and software for photoacoustic technologies is urging the establishment of dedicated tools for standardization and performance assessment. In particular, the fabrication of anatomical phantoms for photoacoustic imaging remains an open question, as current solutions have not yet gained unanimous support. Here, we propose that a hybrid material made of a water-in-oil emulsion of glycerol and polydimethylsiloxane may represent a versatile platform to host a broad taxonomy of hydrophobic and hydrophilic dyes and recapitulate the optical and acoustic features of bio tissue. For a full optical parameterization, we refer to Wrohel, et al. [Biorned. Opt. Express 7, 2088 (2016)], where this material was first presented for optical imaging. Instead, here, we complete the picture and find that its speed of sound and acoustic attenuation resemble those of pure polydimethylsiloxane, i.e. respectively 1150 +/- 30 m/s and 3.5 +/- 0.4 dB/(MHz.cm). We demonstrate its use under a commercial B-mode scanner and a home-made A-mode stage for photoacoustic analysis to retrieve the ground-truth encoded in a multilayer architecture containing indocyanine green, plasmonic particles and red blood cells. Finally, we verify the stability of its acoustic, optical and geometric features over a time span of three months. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement |
| اللغة: | English |
| DOI: | 10.1364/BOE.10.003719 |
| DOI: | 10.003719/rivista:Biomedical |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65966a542485b3c87fccd48a78e2ba8 https://europepmc.org/articles/PMC6701555/ |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e65966a542485b3c87fccd48a78e2ba8 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1364/BOE.10.003719 |
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