Patent foramen ovale closure versus medical therapy for cryptogenic stroke: An updated systematic review and meta-analysis
| العنوان: | Patent foramen ovale closure versus medical therapy for cryptogenic stroke: An updated systematic review and meta-analysis |
|---|---|
| المؤلفون: | Elina Zakin, Robert Frankel, Ravi Teja Pasam, Bilal Malik, Shanti Patel, Jacob Shani, Sergey Ayzenberg, Joseph Gotesman, Sunny Goel |
| المصدر: | Indian Heart Journal, Vol 71, Iss 6, Pp 446-453 (2019) Indian Heart Journal |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, RD1-811, Septal Occluder Device, Foramen Ovale, Patent, Cryptogenic stroke, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Secondary Prevention, medicine, Forest plot, Humans, Diseases of the circulatory (Cardiovascular) system, 030212 general & internal medicine, Recurrent stroke, Stroke, business.industry, Antiplatelet therapy, Anticoagulants, Atrial fibrillation, medicine.disease, Clinical trial, Originaln Article, Meta-analysis, Relative risk, RC666-701, Patent foramen ovale, Patent foramen closure, Surgery, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors |
| الوصف: | Objectives: The objective of this study was to compare safety and efficacy of patent foramen ovale (PFO) closure compared with medical therapy in patients with cryptogenic stroke (CS). Background: The role of PFO closure in preventing recurrent stroke in patients with prior CS has been controversial. Methods: We searched PubMed, EMBASE, the Cochrane Central Register of Controlled trials, and the clinical trial registry maintained at clinicaltrials.gov for randomized control trials that compared device closure with medical management and reported on subsequent stroke and adverse events. Event rates were compared using a forest plot of relative risk using a random-effects model assuming interstudy heterogeneity. Results: A total of 6 studies (n = 3747) were included in the final analysis. Mean follow-up ranged from 2 to 5.9 years. Pooled analysis revealed that device closure compared to medical management was associated with a significant reduction in stroke (risk ratio [RR] = 0.41, 95% CI = 0.20–0.83, I2 = 51%, P = 0.01). There was, however, a significant increase in atrial fibrillation with device therapy (RR = 5.29, 95% CI = 2.32–12.06, I2 = 38%, P |
| اللغة: | English |
| تدمد: | 0019-4832 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65302cf02e5304dce7174e307e7fedb http://www.sciencedirect.com/science/article/pii/S0019483219304328 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e65302cf02e5304dce7174e307e7fedb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00194832 |
|---|