Prefrontostriatal Circuitry Regulates Effort-Related Decision Making
| العنوان: | Prefrontostriatal Circuitry Regulates Effort-Related Decision Making |
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| المؤلفون: | Wolfgang Hauber, Susanne Sommer |
| المصدر: | Cerebral Cortex. 19:2240-2247 |
| بيانات النشر: | Oxford University Press (OUP), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Cognitive Neuroscience, Physical Exertion, Excitotoxic lesion, Nucleus accumbens, Choice Behavior, Gyrus Cinguli, Nucleus Accumbens, Discrimination Learning, Rats, Sprague-Dawley, Anterior cingulate gyrus, Cellular and Molecular Neuroscience, Reward, Dopamine, Neural Pathways, medicine, Animals, Neural system, Anterior cingulate cortex, Analysis of Variance, Quinolinic Acid, Rats, medicine.anatomical_structure, Disconnection, Psychology, Neuroscience, psychological phenomena and processes, medicine.drug, Basolateral amygdala |
| الوصف: | The anterior cingulate cortex (ACC), the basolateral amygdala (BLA), and the dopamine in the nucleus accumbens (NAc) are part of a neural system that is critically involved in making decisions on how much effort to invest for rewards. In the present study, we sought to identify functional interactions between ACC and NAc regulating effort-based decision making. Rats were tested in a T-maze cost-benefit task in which they could either choose to climb a barrier to obtain a large reward (LR) in one arm or a small reward in the other arm without a barrier. Experiment 1 revealed that bilateral excitotoxic lesions of the core subregion of the NAc impaired effort-based decision making, that is, reduced the preference for the high effort-LR option when having the choice to obtain a low reward with little effort. Experiment 2 showed that disconnection of the ACC and NAc core using an asymmetrical excitotoxic lesion procedure impaired effort-based decision making. The present data provide evidence that effort-based decision making is governed by an interconnected neural system that requires serial information transfer between ACC and NAc core. |
| تدمد: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhn241 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6418e21da16856ce22e027240b14f98 https://doi.org/10.1093/cercor/bhn241 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e6418e21da16856ce22e027240b14f98 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602199 10473211 |
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| DOI: | 10.1093/cercor/bhn241 |