Effects of Enalapril on the Exercise Capacity and Neurohumoral Factors during Exercise in Patients with Chronic Heart Failure
| العنوان: | Effects of Enalapril on the Exercise Capacity and Neurohumoral Factors during Exercise in Patients with Chronic Heart Failure |
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| المؤلفون: | Hideyuki Kitamura, Kazuhide Ogino, Hiroto Mashiba, Hiroyuki Miyakoda, Toru Kinugawa, Hiroshi Kotake, Hiroki Omodani, Masahiko Kato, Shuichi Osaki, Noriyasu Noguchi, Tatsuhiko Matsumoto |
| المصدر: | Cardiology. 88:6-13 |
| بيانات النشر: | S. Karger AG, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Anaerobic Threshold, Heart disease, Radioimmunoassay, Angiotensin-Converting Enzyme Inhibitors, Physical exercise, Electrocardiography, Enalapril, Atrial natriuretic peptide, Internal medicine, Humans, Medicine, Pharmacology (medical), cardiovascular diseases, Exercise, Aged, Aged, 80 and over, Heart Failure, Neurotransmitter Agents, Exercise Tolerance, Dose-Response Relationship, Drug, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Angiotensin II, Surgery, Echocardiography, Heart failure, Chronic Disease, Cardiology, Radiography, Thoracic, Blood Gas Analysis, Cardiology and Cardiovascular Medicine, business, Anaerobic exercise, circulatory and respiratory physiology, medicine.drug |
| الوصف: | The effects of enalapril on exercise capacity and neurohumoral factors during exercise were evaluated in 10 patients with heart failure. Echocardiograms and exercise testing with expired gas analysis were performed before and after enalapril. Blood samples were obtained before and after exercise. Both ejection fraction and percent fractional shortening increased with enalapril (p0.05). The anaerobic threshold and peak VO2 did not change with enalapril. Epinephrine and norepinephrine levels at peak exercise decreased with enalapril (p0.1). Plasma renin both at rest and at peak exercise increased with enalapril (p0.1). Angiotensin II was lower after enalapril both at rest and at peak exercise (p0.1 and p0.05, respectively). Aldosterone was lower after enalapril both at rest and at peak exercise (p0.05). Atrial natriuretic peptide (ANP) was lower after enalapril both at rest and at peak exercise. There was no significant correlations between peak VO2 and changes in neurohumoral factors before and after enalapril during exercise. In conclusion, neurohumoral changes with enalapril occurred during exercise even if exercise capacity did not improve. Moreover, the improvement of cardiac function at rest and neurohumoral factors with enalapril did not lead to a change of exercise capacity. |
| تدمد: | 1421-9751 0008-6312 |
| DOI: | 10.1159/000177302 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61931229337435ba34f55c710a1ac25 https://doi.org/10.1159/000177302 |
| رقم الانضمام: | edsair.doi.dedup.....e61931229337435ba34f55c710a1ac25 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219751 00086312 |
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| DOI: | 10.1159/000177302 |