التفاصيل البيبلوغرافية
| العنوان: |
Predictors of progression from moderate to severe coronavirus disease 2019: a retrospective cohort |
| المؤلفون: |
Biao Cheng, Xiaowu Shi, Xiao-chao Li, Guoliang Yang, Yuchen Chen, Aiping Deng, Xiuran Zuo, Jian Chen, Jiahao Hu |
| المصدر: |
Clinical Microbiology and Infection |
| بيانات النشر: |
Elsevier BV, 2020. |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
Male, 0301 basic medicine, moderate, Logistic regression, Severity of Illness Index, COVID-19 Testing, 0302 clinical medicine, Risk Factors, Medicine, Lymphocytes, 030212 general & internal medicine, predict, General Medicine, Middle Aged, Prognosis, Anti-Bacterial Agents, C-Reactive Protein, Infectious Diseases, Area Under Curve, Disease Progression, Absolute neutrophil count, Female, Coronavirus Infections, Adult, Moderate to severe, Microbiology (medical), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Pneumonia, Viral, 030106 microbiology, Antiviral Agents, Article, Betacoronavirus, 03 medical and health sciences, Internal medicine, Severity of illness, Humans, Lymphocyte Count, neutrophil-lymphocyte ratio, Pandemics, Survival analysis, Retrospective Studies, Clinical Laboratory Techniques, SARS-CoV-2, business.industry, Dry cough, COVID-19, Retrospective cohort study, Survival Analysis, ROC Curve, business, Biomarkers |
| الوصف: |
Most cases of coronavirus disease 2019 (COVID-19) are identified as moderate, which is defined as having a fever or dry cough and lung imaging with ground-glass opacities. The risk factors and predictors of prognosis in such cohorts remain uncertain.All adults with COVID-19 of moderate severity diagnosed using quantitative RT-PCR and hospitalized at the Central Hospital of Wuhan, China, from 1 January to 20 March 2020 were enrolled in this retrospective study. The main outcomes were progression from moderate to severe or critical condition or death.Among the 456 enrolled patients with moderate COVID-19, 251/456 (55.0%) had poor prognosis. Multivariate logistic regression analysis identified higher neutrophil count: lymphocyte count ratio (NLR) on admission (OR 1.032, 95% CI 1.042-1.230, p 0.004) and higher C-reactive protein (CRP) on admission (OR 3.017, 95% CI 1.941-4.690, p 0.001) were associated with increased OR of poor prognosis. The area under the receiver operating characteristic curve (AUC) for NLR and CRP in predicting progression to critical condition was 0.77 (95% CI 0.694-0.846, p 0.001) and 0.84 (95% CI 0.780-0.905, p 0.001), with a cut-off value of 2.79 and 25.95 mg/L, respectively. The AUC of NLR and CRP in predicting death was 0.81 (95% CI 0.732-0.878, p 0.001) and 0.89 (95% CI 0.825-0.946, p 0.001), with a cut-off value of 3.19 and 33.4 mg/L, respectively.Higher levels of NLR and CRP at admission were associated with poor prognosis of individuals with moderate COVID-19. NLR and CRP were good predictors of progression to critical condition and death. |
| اللغة: |
English |
| تدمد: |
1198-743X |
| DOI: |
10.1016/j.cmi.2020.06.033 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e29564f8275fc6a1b709999ecce461 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....e5e29564f8275fc6a1b709999ecce461 |
| قاعدة البيانات: |
OpenAIRE |