The Association of Age and Frailty with the Pharmacokinetics and Pharmacodynamics of Metoclopramide
| العنوان: | The Association of Age and Frailty with the Pharmacokinetics and Pharmacodynamics of Metoclopramide |
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| المؤلفون: | Alan V. Boddy, Hilary Wynne, K. W. Woodhouse, Catherine Yelland, L. H. Cope, D. N. Bateman |
| المصدر: | Age and Ageing. 22:354-359 |
| بيانات النشر: | Oxford University Press (OUP), 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Adult, Male, Aging, Metoclopramide, Metabolic Clearance Rate, Frail Elderly, Sedation, Administration, Oral, Akathisia, law.invention, Randomized controlled trial, Pharmacokinetics, Reference Values, law, Oral administration, Humans, Medicine, Infusions, Intravenous, Aged, Neurologic Examination, business.industry, Dopamine antagonist, General Medicine, Pharmacodynamics, Anesthesia, Female, Geriatrics and Gerontology, medicine.symptom, business, medicine.drug |
| الوصف: | We have investigated the association of age and frailty with the pharmacokinetics and pharmacodynamics of the conjugated drug, metoclopramide. Six healthy young, six healthy elderly (> 65 years), and six frail elderly (> 65 years) subjects were studied on two occasions, receiving 10 mg metoclopramide by intravenous bolus and orally, in random order. Blood and urine were collected for measurement of pharmacokinetic parameters. Liver volume was measured by ultrasound. Sedation and contentment were self-recorded on visual analogue scales. Liver volume was not significantly different in the three groups, nor was bio-availability of metoclopramide. Clearance was similar in the young and fit elderly but reduced in the frail elderly subjects when compared with the young (p < 0.05), both when expressed in absolute terms and per unit liver volume. There were no differences in percentages cleared as the free drug or as the sulphate or glucuronide metabolite within or between groups, suggesting that frailty can produce a general impairment of conjugation pathways. The frail elderly subjects reported more sedation after intravenous dosage than the other subjects, whilst only young subjects reported akathisia. This did not relate to pharmacokinetic differences and seemed therefore to reflect associated pharmacodynamic changes in specific receptor or target sites. |
| تدمد: | 1468-2834 0002-0729 |
| DOI: | 10.1093/ageing/22.5.354 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a9373acc3ccf900e0aa2fa66cac77e https://doi.org/10.1093/ageing/22.5.354 |
| رقم الانضمام: | edsair.doi.dedup.....e5a9373acc3ccf900e0aa2fa66cac77e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682834 00020729 |
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| DOI: | 10.1093/ageing/22.5.354 |