Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Premature Ovarian Insufficiency in Chinese Women
| العنوان: | Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Premature Ovarian Insufficiency in Chinese Women |
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| المؤلفون: | Rui Pan, Suyun Zhang, Jie Wu, Jianwei Xiong, Rongrong Tan, Ying Tian, Ling Chen |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 103:2543-2551 |
| بيانات النشر: | The Endocrine Society, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, China, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Context (language use), Endocrine Disruptors, Primary Ovarian Insufficiency, 010501 environmental sciences, Logistic regression, Premature ovarian insufficiency, 01 natural sciences, Biochemistry, 03 medical and health sciences, Follicle-stimulating hormone, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Risk Factors, Internal medicine, medicine, Humans, 0105 earth and related environmental sciences, Fluorocarbons, 030219 obstetrics & reproductive medicine, Triiodothyronine, Estradiol, business.industry, Biochemistry (medical), Case-control study, Environmental Exposure, Environmental exposure, Prolactin, Thyroxine, Perfluorooctane, Alkanesulfonic Acids, chemistry, Case-Control Studies, Linear Models, Regression Analysis, Environmental Pollutants, Female, Caprylates, Follicle Stimulating Hormone, Sulfonic Acids, business |
| الوصف: | Context Perfluoroalkyl and polyfluoroalkyl substances (PFASs), a group of ubiquitous environmental chemicals with properties of endocrine disruption, are often detectable in humans. Objective The current study investigated the association between exposure to PFAS and primary ovarian insufficiency (POI). Design, Patients, Interventions, and Main Outcome Measures Levels of plasma PFAS were measured in 120 Chinese women with overt POI and 120 healthy control subjects from 2013 to 2016. Associations between PFAS levels and odds of POI, as well as hormonal profiles, were evaluated using multiple logistic regression and multiple linear regression models. Results Levels of perfluorooctanate (PFOA), perfluorooctane sulfonate (PFOS), and perfluorohexanesulfonate (PFHxS) were positively associated with the risks of POI (highest vs. lowest tertile, PFOA: OR, 3.80; 95% CI, 1.92–7.49; PFOS: OR, 2.81; 95% CI, 1.46–5.41; PFHxS: OR, 6.63; 95% CI, 3.22–13.65). In patients with POI, levels of PFOS and PFHxS exposure were positively associated with FSH (PFOS: adjusted β, 0.26; 95% CI, 0.15 to 0.38; PFHxS: adjusted β, 0.16; 95% CI, 0.04 to 0.28) and negatively associated with estradiol (PFOS: adjusted β, −0.30; 95% CI, −0.47 to −0.12; PFHxS: adjusted β, −0.19; 95% CI, −0.37 to −0.02). Exposure to PFOS and PFOA was associated with elevation of prolactin (PFOS: adjusted β, 0.17; 95% CI, 0.06 to 0.29; PFOA: adjusted β, 0.16; 95% CI, 0.01 to 0.30) or with a decrease of free triiodothyronine (PFOS: adjusted β, −0.88; 95% CI, −1.64 to −0.09; PFOA: adjusted β, −0.90; 95% CI, −1.88 to 0.09) and thyroxine (PFOS: adjusted β, −2.99; 95% CI, −4.52 to −1.46; PFOA: adjusted β, −3.42; 95% CI, −5.39 to −1.46). Conclusion High exposure to PFOA, PFOS, and PFHxS is associated with increased risk of POI in humans. |
| تدمد: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2017-02783 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54fb4e3b362ae6e755fdb5bdd173210 https://doi.org/10.1210/jc.2017-02783 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e54fb4e3b362ae6e755fdb5bdd173210 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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| DOI: | 10.1210/jc.2017-02783 |