No increased risk of flare in ulcerative colitis patients in corticosteroid‐free remission after stopping 5‐aminosalicylic acid: A territory‐wide population‐based study
| العنوان: | No increased risk of flare in ulcerative colitis patients in corticosteroid‐free remission after stopping 5‐aminosalicylic acid: A territory‐wide population‐based study |
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| المؤلفون: | Joyce W Y Mak, Nobel T K Yuen, Terry C F Yip, Ray H M Lam, Brian K H Lam, Cherry T Y Cheng, Grace L H Wong, Francis K L Chan, Siew C Ng |
| المصدر: | Journal of Gastroenterology and Hepatology. 37:1284-1289 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Hepatology, Adrenal Cortex Hormones, Anti-Inflammatory Agents, Non-Steroidal, Remission Induction, Gastroenterology, Humans, Colitis, Ulcerative, Mesalamine, Retrospective Studies |
| الوصف: | Whether 5-aminosalicylic acid (ASA) can be stopped in patients with stable ulcerative colitis (UC) remains unclear. We aimed to examine whether 5-ASA can be safely withdrawn in UC patients who have been in corticosteroid-free clinical remission for ≥ 1 year.This is a retrospective cohort study using territory-wide healthcare database in Hong Kong. Primary outcome was development of UC flare, defined as new corticosteroid use or UC-related hospitalizations within 5 years. UC patients on oral 5-ASA ≥ 2 g daily for ≥ 1 year with C-reactive protein (CRP) 10 mg/dL and no 5-ASA dosage escalation, UC-related hospitalization or corticosteroid use in the past year were included. Patients on biological agents were excluded. Patients were classified as "stopping" if 5-ASA was withdrawn for ≥ 90 days within follow-up period. We performed multivariable Cox regression models adjusting for demographics, blood parameters and immunosuppressants used. Adjusted hazard ratio (aHR) with 95% confidence interval (CI) was reported comparing stopping and continuous-use groups.A total of 1408 patients were included with a median follow-up duration of 41.8 months (interquartile range [IQR]: 17.2-60.0 months). Stopping 5-ASA was not associated with an increased risk of UC flare (aHR 0.91; 95% CI 0.64-1.31; P = 0.620). A higher CRP levels at the time of stopping 5-ASA (aHR 1.15; 95% CI: 1.01-1.30; P = 0.037) were associated with increased risk of flare.Stopping 5-ASA in UC patients in corticosteroid-free remission for ≥ 1 year was not associated with increased risk of flare. Future prospective trials should evaluate the role of stopping 5-ASA in stable UC patients. |
| تدمد: | 1440-1746 0815-9319 |
| DOI: | 10.1111/jgh.15838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49a7ff72d92582a229417c3bd2b90dd https://doi.org/10.1111/jgh.15838 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e49a7ff72d92582a229417c3bd2b90dd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401746 08159319 |
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| DOI: | 10.1111/jgh.15838 |