VOLTAMMETRIC AND CHROMATOGRAPHIC DETERMINATION OF NAPROXEN IN DRUG FORMULATION
| العنوان: | VOLTAMMETRIC AND CHROMATOGRAPHIC DETERMINATION OF NAPROXEN IN DRUG FORMULATION |
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| المؤلفون: | Ozlem Tonguc Yayintas, Gulsen Saglikoglu, Murat Sadikoglu, Selehattin Yilmaz, Suzan Yanik |
| المصدر: | Volume: 3, Issue: 4 299-310 Journal of Scientific Perspectives |
| بيانات النشر: | Rating Academy, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Detection limit, Naproxen, Chromatography, Fen, Chemistry, musculoskeletal, neural, and ocular physiology, Science, fungi, commercial drug tablets.,naproxen,voltammetric method,differential pulse voltammetry,cyclic voltammetry,high performance liquid chromatography,ultra-trace graphite electrode, Electrolyte, Pharmaceutical formulation, High-performance liquid chromatography, Nap, naproxen,voltammetric method,differential pulse voltammetry,cyclic voltammetry,high performance liquid chromatography,ultra-trace graphite electrode,commercial drug tablets, mental disorders, medicine, Differential pulse voltammetry, Cyclic voltammetry, human activities, psychological phenomena and processes, medicine.drug |
| الوصف: | In this work, the electrochemical oxidation of naproxen (NAP) was studied at an ultra-trace graphite electrode (UTGE). The cyclic voltammetry (CV) technique was used to determine the optimum conditions and the effect of pH on the electrochemical oxidation of NAP. Acetate buffer (pH 4.50) was selected as the support electrolyte due to obtaining the highest electronic signal increase during oxidation of NAP at UTGE. The differential pulse voltammetry (DPV) technique was performed for electrochemical determination of NAP. In the optimum conditions, the limits of detection (LOD) and quantification (LOQ) were determined to be 8.6610-8 M and 2.8810-7 M. In addition, the amount of NAP was determined in drug tablets. The recovery studies of NAP from the drug tablet were completed in order to check the accuracy and precision of the applied voltammetric method. Furthermore, the determination of NAP was performed with the high-performance liquid chromatography (HPLC) method. These two methods were compared in terms of accuracy, precision and recovery studies. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2587-3008 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e450beb538227dd25218a79eab9099df https://dergipark.org.tr/tr/pub/jsp/issue/50093/642790 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e450beb538227dd25218a79eab9099df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25873008 |
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