Phage therapy for severe bacterial infections: a narrative review
| العنوان: | Phage therapy for severe bacterial infections: a narrative review |
|---|---|
| المؤلفون: | Carola Venturini, Nouri L. Ben Zakour, Indy Sandaradura, Aleksandra Petrovic Fabijan, Bethany Bowring, Jonathan R. Iredell, Susan Maddocks, Josephine Ho, Ali Khalid, Ruby C.Y. Lin, Timothy Gilbey |
| المصدر: | Medical Journal of Australia. 212:279-285 |
| بيانات النشر: | AMPCo, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Phage therapy, biology, business.industry, viruses, medicine.medical_treatment, Treatment options, Bacterial Infections, General Medicine, biology.organism_classification, Bacteriophage, 03 medical and health sciences, 0302 clinical medicine, Lytic cycle, In vivo, Immunology, medicine, Humans, Bacteriophages, Narrative review, Good manufacturing practice, Phage Therapy, 030212 general & internal medicine, Dosing, business |
| الوصف: | Bacteriophage (phage) therapy is re-emerging a century after it began. Activity against antibiotic-resistant pathogens and a lack of serious side effects make phage therapy an attractive treatment option in refractory bacterial infections. Phages are highly specific for their bacterial targets, but the relationship between in vitro activity and in vivo efficacy remains to be rigorously evaluated. Pharmacokinetic and pharmacodynamic principles of phage therapy are generally based on the classic predator-prey relationship, but numerous other factors contribute to phage clearance and optimal dosing strategies remain unclear. Combinations of fully characterised, exclusively lytic phages prepared under good manufacturing practice are limited in their availability. Safety has been demonstrated but randomised controlled trials are needed to evaluate efficacy. |
| تدمد: | 1326-5377 0025-729X |
| DOI: | 10.5694/mja2.50355 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38765459202ab0d03c23506749f3931 https://doi.org/10.5694/mja2.50355 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e38765459202ab0d03c23506749f3931 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13265377 0025729X |
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| DOI: | 10.5694/mja2.50355 |