Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53N236S Mouse Embryonic Fibroblasts
| العنوان: | Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53N236S Mouse Embryonic Fibroblasts |
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| المؤلفون: | Hui Zhu, Wen-Ru Tang, Jiang Du, Ming-Hua Qiu, Yin Nian, Yin Luo |
| المصدر: | Journal of Natural Products. 76:896-902 |
| بيانات النشر: | American Chemical Society (ACS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Cimicifuga, Stereochemistry, Molecular Conformation, Pharmaceutical Science, Biology, Crystallography, X-Ray, medicine.disease_cause, Analytical Chemistry, Terpene, Inhibitory Concentration 50, Mice, Triterpene, Drug Discovery, medicine, Animals, Humans, Nuclear Magnetic Resonance, Biomolecular, IC50, Cell Proliferation, Pharmacology, chemistry.chemical_classification, Cimicifuga yunnanensis, Mutation, Molecular Structure, Organic Chemistry, Wild type, Fibroblasts, Embryonic stem cell, Triterpenes, Complementary and alternative medicine, chemistry, Cell culture, Molecular Medicine, Tumor Suppressor Protein p53, Drugs, Chinese Herbal |
| الوصف: | Nine new triterpene derivatives, yunnanterpenes A-F (1-6), 15,16-seco-cimiterpenes A and B (7, 8), and cimilactone C (9), and 15 known analogues (10-24) were isolated from the aerial parts of Cimicifuga yunnanensis. The new structures were established using a combination of MS, NMR, and single-crystal X-ray diffraction techniques. WT MEFs (wildtype mouse embryonic fibroblasts) and tumorigenic cell lines p53(-/-)+H-RasV12 and ps3(-/-)+p53(N236S)+H-RasV12 were used for evaluating active structures, targeting p53(N236S) (corresponding to p53(N239S) in humans) mutation. Compound 5 showed nonselective activities against these cell lines, with IC50 values of 5.8, 8.6, and 6.0 mu M, respectively. Compound 4 exhibited greater selectivity against the p53(-/-)+p53(N236S)+H-RasV12 cells (IC50 5.5 mu M) than against the WT MEFs cells (IC50 14.3 mu M). |
| تدمد: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np4000262 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3398a947b5a6a0dc54043797c334bdf https://doi.org/10.1021/np4000262 |
| رقم الانضمام: | edsair.doi.dedup.....e3398a947b5a6a0dc54043797c334bdf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206025 01633864 |
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| DOI: | 10.1021/np4000262 |