Effects of the excretory/secretory products of Trichostrongylus colubriformis on the growth of different cell lines
| العنوان: | Effects of the excretory/secretory products of Trichostrongylus colubriformis on the growth of different cell lines |
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| المؤلفون: | Florence Huby, Jean-Louis Nano, S. Mallet, Hervé Hoste |
| المساهمون: | Station de Pathologie aviaire et parasitologie [Nouzilly] (PAP), Institut National de la Recherche Agronomique (INRA), ProdInra, Migration |
| المصدر: | International Journal for Parasitology International Journal for Parasitology, Elsevier, 1999, 29 (5), pp.697-702 |
| بيانات النشر: | Elsevier BV, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Trichostrongylus, Crypt, Cell Count, CHO Cells, Cell Line, 030308 mycology & parasitology, Mice, MITOGENE, 03 medical and health sciences, Dogs, Cricetinae, medicine, Animals, Fibroblast, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, biology, Cell growth, 3T3 Cells, Helminth Proteins, biology.organism_classification, Molecular biology, Epithelium, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Infectious Diseases, medicine.anatomical_structure, Nematode, Excretory system, Cell culture, Hepatocyte, Immunology, Female, Parasitology, Rabbits, Cell Division |
| الوصف: | The effects of the excretory/secretory (ES) products of the parasitic nematode Trichostrongylus colubriformis were examined on the proliferation of seven cell lines derived from a digestive or non-digestive origin. The excretory/secretory products of T. colubriformis were incorporated in the culture medium of the different cell lines and cell proliferation was measured by means of the 5-bromo-2′-deoxy-uridine (Brdu) assay. An increase in cell numbers was found with the three epithelial intestinal cells (RIC, IEC-6, IRD-98) and with epithelial kidney cells (MDCK). In contrast, an inhibition in the proliferation of epithelial ovarian cells (CHO) and fibroblasts (3T3) was observed with the addition of the excretory/secretory products and no effect was detected on the cell growth of hepatocytes (HepG2). These data are discussed with respect to the tissue specificity of the existing mitogenic effect of the worms on the intestinal crypt cells during parasitism. |
| تدمد: | 0020-7519 |
| DOI: | 10.1016/s0020-7519(99)00014-4 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e315a7733202613a54934bbb49df4b51 https://doi.org/10.1016/s0020-7519(99)00014-4 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e315a7733202613a54934bbb49df4b51 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00207519 |
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| DOI: | 10.1016/s0020-7519(99)00014-4 |