PURPOSE: To evaluate recent trends in inpatient postoperative utilization of opioid and non-opioid analgesics in US hospitals. METHODS: Using Premier Research database (October 2007 – September 2017), we identified adults who were hospitalized for inpatient surgical procedures (N = 6,068,133). For each month, we calculated proportion of patients admitted that month who were administered (1) opioids, (2) acetaminophen, (3) non-steroidal anti-inflammatory drugs (NSADs), and (4) gabapentinoids (gabapentin or pregabalin) during the postoperative period, defined as inpatient postoperative days 1–7, unless discharged earlier. For patients administered opioids, we estimated total and average daily postoperative opioid dose in morphine milligrams equivalents (MMEs). Monthly measures were standardized to the distribution of surgeries and the length of postoperative stay within each surgery during the last year of available data. RESULTS: Overall, 90.8% of patients were administered opioids postoperatively; mean total postoperative dose was 304 MMEs (median 130). Both the frequency and the amount of opioids administered remained stable over 2007–2017. Postoperative use of acetaminophen increased from mean standardized monthly prevalence of 78% in 2007–2008 to 85% in 2017, while the use of NSAIDs remained stable at a standardized mean of 37%. The use of gabapentinoids increased from below 10% in 2007–2008 to the mean standardized monthly prevalence of 23% in 2017. CONCLUSION: Despite growing awareness of risks associated with postoperative opioid use, we observed no change in postoperative utilization of opioids in US hospitals. Increasing the use of non-opioid pain management approaches, could constitute an important target in our efforts to curtail US opioid epidemic.