Two new withanolides from the whole plants of Physalis peruviana
| العنوان: | Two new withanolides from the whole plants of Physalis peruviana |
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| المؤلفون: | Li, Qian-Ran, Liang, Hui-Jun, Li, Bai-Lin, Ao, Zhuo-Yi, Fan, Yu-Wen, Zhang, Wei-Jie, Lian, Xin, Chen, Jia-Yan, Hu, Juan-Juan, Yuan, Jie, Wu, Jie-Wei |
| المصدر: | Journal of Asian Natural Products Research. 25:349-356 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology, Complementary and alternative medicine, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, General Medicine, Analytical Chemistry |
| الوصف: | Two new withaphysalin-type withanolides (18-O-ethylwithaphysalin R and 5-O-ethylphysaminimin C, 1 and 2), along with twelve known withanolides (3–14), were purified and identified from Physalis peruviana L. The chemical structures of these new isolates were elucidated through analyzing spectroscopic and HRESIMS data. All the obtained metabolites were appraised for their potential antiproliferative activity against the human breast cancer cell line MCF-7. Compound 7 was discovered to exhibit potent activity with an IC50 value of 3.51 µM and compounds 2, 6 and 14 showed weak cytotoxic effect. |
| تدمد: | 1477-2213 1028-6020 |
| DOI: | 10.1080/10286020.2022.2095263 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2894de8d7cecaa9fd373fbf44308826 https://doi.org/10.1080/10286020.2022.2095263 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e2894de8d7cecaa9fd373fbf44308826 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14772213 10286020 |
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| DOI: | 10.1080/10286020.2022.2095263 |