Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging
| العنوان: | Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging |
|---|---|
| المؤلفون: | Sabrina M. Albertson, Mark W. Bondi, David S. Knopman, Michelle M. Mielke, Mary M. Machulda, Ronald C. Petersen, Emily S. Lundt, Walter K. Kremers |
| المصدر: | Alzheimers Dement |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Aging, Epidemiology, Disease, Neuropsychological Tests, Disease cluster, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, Neuroimaging, mental disorders, medicine, Cluster Analysis, Humans, Dementia, Cognitive Dysfunction, Longitudinal Studies, Cognitive impairment, Aged, 80 and over, 030214 geriatrics, Receiver operating characteristic, business.industry, Health Policy, Neuropsychology, medicine.disease, United States, Normal group, Psychiatry and Mental health, Female, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Clinical psychology |
| الوصف: | Introduction We evaluated whether incident mild cognitive impairment (MCI) subtypes could be empirically derived in the Mayo Clinic Study of Aging. Methods We performed cluster analysis on neuropsychological data from 506 participants with incident MCI. Results The 3-cluster solution resulted in (1) amnestic, (2) dysexecutive, (3) dysnomic subtypes. The 4-cluster solution produced these same three groups and a fourth group with subtle cognitive impairment (SCI). The SCI cluster was a subset of the amnestic cluster and distinct from well-matched cognitively unimpaired participants based on memory and global z-score area under the receiver operating characteristic curve analyses and probability of progression to MCI/dementia. Discussion We empirically identified three neuropsychological subtypes of MCI that share some features with MCI subtypes identified in the Alzheimer's Disease Neuroimaging Initiative. The fourth subtype with SCI in the Mayo Clinic Study of Aging differed from the fourth cluster-derived normal group in Alzheimer's Disease Neuroimaging Initiative and could represent a group to target with early interventions. |
| تدمد: | 1552-5279 1552-5260 |
| DOI: | 10.1016/j.jalz.2019.03.014 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25cdffc6b24599adbbc08cb14f0d4fc https://doi.org/10.1016/j.jalz.2019.03.014 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e25cdffc6b24599adbbc08cb14f0d4fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15525279 15525260 |
|---|---|
| DOI: | 10.1016/j.jalz.2019.03.014 |